{"id":"W4402069975","doi":"10.3389/fcimb.2024.1434939","title":"Small molecule inhibitors of fungal Δ(9) fatty acid desaturase as antifungal agents against Candida auris","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Université Laval; Montreal Heart Institute","funders":"Centers for Disease Control and Prevention; Institut de Cardiologie de Montréal; Public Health Agency; Public Health Agency of Canada","keywords":"Candida auris; Microbiology; Candida albicans; Galleria mellonella; Biology; Pathogen; Biofilm; Fungal pathogen; Caspofungin; Human pathogen; Corpus albicans; Antimicrobial; Virulence; Amphotericin B; Antifungal; Biochemistry; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044057,0.0003997213,0.0003329326,0.0003475762,0.0001195257,0.0002240886,0.0002475268,0.0002476032,0.001100929],"category_scores_gemma":[0.00006970765,0.0001164908,0.0003048666,0.0002552567,0.0001204078,0.0001283062,0.0001760231,0.0005173064,0.0002767404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984482,"about_ca_system_score_gemma":0.0001842806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007539396,"about_ca_topic_score_gemma":0.002650843,"domain_scores_codex":[0.9999385,0.000008464054,0.000005300611,0.00001068201,0.00001967471,0.00001739803],"domain_scores_gemma":[0.999972,0.000003834106,0.000006854832,0.000001976721,0.000005934943,0.000009376371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004473002,0.0001361958,0.0002496374,0.0003243919,0.00003310296,0.0002021423,0.00001708207,0.0004574779,0.9820853,0.0001752664,0.0004889906,0.01538304],"study_design_scores_gemma":[0.0003925714,0.003573177,0.007673378,0.00007856169,0.0001725357,0.0007140293,0.00006109097,0.002310857,0.9551495,0.0001266745,0.02971485,0.00003282424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457538,0.03623248,0.004634421,0.0004909697,0.0002093393,0.0003502313,0.002549635,0.0004625031,0.00931664],"genre_scores_gemma":[0.9687755,0.0188873,0.004288873,0.0003693742,0.00004038972,0.0001378965,0.002238873,0.00001755527,0.005244105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100929,"threshold_uncertainty_score":0.003682971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140813516762624,"score_gpt":0.2409143977510503,"score_spread":0.2295062625834241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}