{"id":"W4402082818","doi":"10.1016/j.bbi.2024.07.047","title":"Constitutive DAMPs in CNS injury: From preclinical insights to clinical perspectives","year":2024,"lang":"en","type":"review","venue":"Brain Behavior and Immunity","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Wings for Life","keywords":"Inflammation; Chemokine; Proinflammatory cytokine; Cell biology; Biology; Receptor; Immune system; Neuroscience; Signal transduction; Damp; Microglia; Cell adhesion molecule; Intracellular; Extracellular; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002435516,0.001066147,0.001337346,0.001084926,0.0002520704,0.002042185,0.0009120982,0.00174675,0.003386367],"category_scores_gemma":[0.001556997,0.0002430731,0.0004825709,0.0007057737,0.001195277,0.002320372,0.000815718,0.003515671,0.001900581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006034914,"about_ca_system_score_gemma":0.001367539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004230838,"about_ca_topic_score_gemma":0.001035068,"domain_scores_codex":[0.999626,0.0001136659,0.00004826219,0.00004649712,0.0001063466,0.00005917359],"domain_scores_gemma":[0.9987709,0.0003591109,0.0001696803,0.00008514665,0.0003547297,0.0002604919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00325325,0.002522676,0.001406641,0.01401758,0.0002530764,0.000935569,0.0002471806,0.0009056918,0.02824315,0.01321692,0.04792956,0.8870687],"study_design_scores_gemma":[0.001465552,0.02277393,0.007026371,0.01334293,0.0006746612,0.003837322,0.0004837241,0.001729306,0.01647078,0.02363789,0.9083986,0.0001588902],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00438768,0.9855273,0.0008787623,0.005577769,0.0008157768,0.00005962778,0.0001236878,0.00005928428,0.002570194],"genre_scores_gemma":[0.03105057,0.9599775,0.001539492,0.003497952,0.002063178,0.0001414005,0.0002507004,0.00001880373,0.001460328],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003386367,"threshold_uncertainty_score":0.01288044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129813752896895,"score_gpt":0.4414345826925489,"score_spread":0.3116208297956539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}