{"id":"W4402082947","doi":"10.1016/j.lfs.2024.123033","title":"ALDH and cancer stem cells: Pathways, challenges, and future directions in targeted therapy","year":2024,"lang":"en","type":"review","venue":"Life Sciences","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Cancer stem cell; Cancer research; Aldehyde dehydrogenase; Biology; Cancer; Tumor microenvironment; Bioinformatics; Medicine; Genetics; Enzyme; Biochemistry; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000818656,0.0007049738,0.001442247,0.001493663,0.0002824358,0.001569749,0.0009367049,0.001265684,0.004017146],"category_scores_gemma":[0.0007882805,0.000214352,0.0004039549,0.001796971,0.0007688474,0.001637299,0.0007820387,0.002612982,0.001857836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008167412,"about_ca_system_score_gemma":0.001307479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152632,"about_ca_topic_score_gemma":0.003189349,"domain_scores_codex":[0.999838,0.00003370067,0.00001447313,0.00002290196,0.00006616628,0.0000248271],"domain_scores_gemma":[0.9996412,0.0001748732,0.00003728715,0.00001007971,0.00008944979,0.00004703928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001163355,0.0000748693,0.0001934129,0.00889435,0.00006996598,0.000165646,0.00005060077,0.0004539682,0.001539914,0.009962844,0.04410899,0.9343691],"study_design_scores_gemma":[0.00002569186,0.00008209219,0.0004765733,0.002212268,0.00007429452,0.0005393931,0.00007700185,0.0001370509,0.0003904019,0.004939333,0.9910279,0.00001800065],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005650481,0.998708,0.00008356373,0.0004691347,0.0001641995,0.000001734206,0.00001125522,0.00000533501,0.0005002097],"genre_scores_gemma":[0.0004751736,0.9985285,0.000111073,0.0002583704,0.0002223608,0.000003097729,0.00001684422,7.716411e-7,0.0003837796],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004017146,"threshold_uncertainty_score":0.0134387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1288436106137353,"score_gpt":0.3571603246208137,"score_spread":0.2283167140070783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}