{"id":"W4402083577","doi":"10.1016/j.placenta.2024.07.286","title":"Caspase-7 cleaves gasdermin-E to regulate syncytiotrophoblast pyroptosis","year":2024,"lang":"en","type":"article","venue":"Placenta","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Pyroptosis; Cell biology; Syncytiotrophoblast; Caspase 1; Chemistry; Caspase 8; Caspase; Apoptosis; Biology; Programmed cell death; Biochemistry; Genetics; Placenta; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007440444,0.0001583699,0.0001051752,0.00006799892,0.00007305911,0.00007452531,0.0001594187,0.00009270703,0.0001194882],"category_scores_gemma":[0.00002961597,0.0001518733,0.0001025794,0.0001371206,0.00003745003,0.000005077674,0.0001210983,0.00007709082,0.0004689562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002227985,"about_ca_system_score_gemma":0.00005438728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000250958,"about_ca_topic_score_gemma":0.00002821952,"domain_scores_codex":[0.9990564,0.00002492939,0.0001564014,0.0003602954,0.0001050251,0.0002969563],"domain_scores_gemma":[0.9995474,0.000007499249,0.00001683236,0.0003138564,0.0000293291,0.00008510266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001279849,0.00003140257,0.0002987105,0.00004730746,0.00009322477,0.00002268927,0.0001591208,0.0001019829,0.925954,0.000167897,0.06720553,0.005790098],"study_design_scores_gemma":[0.0002419754,0.0002027164,0.0009521411,0.00005466386,0.00002523673,0.00002565094,0.0002043341,0.0001492533,0.5930476,0.00003296771,0.4047998,0.0002637272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914657,0.001954733,0.0002694804,0.0007926061,0.0004761758,0.0001775218,0.00002743558,0.00004933172,0.004787058],"genre_scores_gemma":[0.9918059,0.0002712481,0.0001796828,0.0005042424,0.0002075659,0.00002353836,0.0001125448,0.0000400649,0.006855211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3375943,"threshold_uncertainty_score":0.6193215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003944107161141111,"score_gpt":0.2376860073105687,"score_spread":0.2337419001494276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}