{"id":"W4402084320","doi":"10.1093/ageing/afae188","title":"Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial","year":2024,"lang":"en","type":"article","venue":"Age and Ageing","topic":"Intensive Care Unit Cognitive Disorders","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Capital Health Research and Development of Special Fund; National Natural Science Foundation of China","keywords":"Medicine; Perioperative; Postoperative cognitive dysfunction; Montreal Cognitive Assessment; Anesthesia; Placebo; Incidence (geometry); Randomized controlled trial; Nasal administration; Elective surgery; Insulin; Surgery; Internal medicine; Cognition; Cognitive impairment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001757605,0.0002596667,0.001322894,0.0003575551,0.00004972378,0.00004638728,0.0000317419,0.0001870445,0.00009232257],"category_scores_gemma":[0.007304534,0.0001758263,0.0004011083,0.0002508397,0.0002938963,0.0001066502,0.00002424554,0.0006665463,0.00001838064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002665784,"about_ca_system_score_gemma":0.00008323752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007868982,"about_ca_topic_score_gemma":0.00004740173,"domain_scores_codex":[0.9975811,0.0008334813,0.0007087066,0.0004437581,0.0002171336,0.0002158734],"domain_scores_gemma":[0.9937231,0.005332672,0.00009501752,0.00008714576,0.0006808574,0.00008120533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9291015,0.0001536671,0.00002285659,0.0002344005,0.0005900705,0.003752221,0.002330267,0.000001131596,0.00005396133,0.0001238385,0.00004544023,0.06359062],"study_design_scores_gemma":[0.9833596,0.006102986,0.0003421706,0.00429075,0.001126514,0.00001165778,0.003218301,0.0009192552,0.0004153835,0.00001556313,0.00003431804,0.0001634943],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857053,0.001494267,0.0004321379,0.0003034857,0.0006128505,0.006581776,0.000007993292,0.00003942625,0.004822822],"genre_scores_gemma":[0.9970886,0.0003125602,0.000006636573,0.001533651,0.0003422371,0.0004363522,0.00006561204,0.00002993688,0.0001843823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06342712,"threshold_uncertainty_score":0.8744737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963683027839278,"score_gpt":0.3398638785843243,"score_spread":0.3202270483059315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}