{"id":"W4402098667","doi":"10.1101/2024.08.29.610372","title":"Epigenomic anomalies in induced pluripotent stem cells from Alzheimer’s disease cases","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hospital for Sick Children; University of Toronto; Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Induced pluripotent stem cell; Epigenomics; Disease; Neuroscience; Human Induced Pluripotent Stem Cells; Biology; Medicine; Embryonic stem cell; Pathology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173401,0.000188028,0.0001018191,0.0007687737,0.0001342243,0.0002276631,0.0001181145,0.000166996,0.001153603],"category_scores_gemma":[0.0002862389,0.00009243541,0.0001592647,0.0003123006,0.000140731,0.000109355,0.0002382594,0.0001524047,0.0001934366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001040811,"about_ca_system_score_gemma":0.00007683189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004213676,"about_ca_topic_score_gemma":0.000565965,"domain_scores_codex":[0.9999077,0.000009683597,0.00001467047,0.00002345283,0.00003074073,0.00001374008],"domain_scores_gemma":[0.9998814,0.00002556608,0.00003659498,0.00001586396,0.00001840083,0.00002218482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007924376,0.00006674763,0.3228929,0.000182363,0.0001414182,0.01738805,0.000626482,0.0003569088,0.6099414,0.00070736,0.000584563,0.04631935],"study_design_scores_gemma":[0.00002102914,0.0002661311,0.8150408,0.00002830983,0.0002060617,0.06469203,0.0003637019,0.0009119552,0.1093446,0.0008978149,0.008214476,0.00001317434],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950221,0.0007718331,0.0015053,0.00002675589,0.000007653724,0.00002389718,0.0004631369,0.00004072365,0.002138655],"genre_scores_gemma":[0.9978347,0.0004466993,0.000534313,0.0000188698,0.000005467419,0.00001266088,0.0008572664,0.000007410734,0.0002825172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153603,"threshold_uncertainty_score":0.003859222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741535091464973,"score_gpt":0.2489844725634158,"score_spread":0.221569121648766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}