{"id":"W4402099356","doi":"10.1002/anie.202414256","title":"Mirror‐Image Random Nonstandard Peptides Integrated Discovery (MI‐RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE European Research Council; Israel Cancer Research Fund; Israel Science Foundation; Japan Society for the Promotion of Science; Thompson Family Foundation; University of Toronto; National Cancer Institute; National Institutes of Health; Hebrew University of Jerusalem; National Institute of Allergy and Infectious Diseases; European Commission; United States - Israel Binational Science Foundation","keywords":"Matrix metalloproteinase; Peptide; Protease; Thioether; Amino acid; Biochemistry; Matrix (chemical analysis); Chemistry; Enzyme; Combinatorial chemistry; Stereochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810972,0.0004856563,0.0002331385,0.0001889615,0.00007306884,0.0002213218,0.0002397045,0.000356665,0.0007546767],"category_scores_gemma":[0.0002148656,0.0001836626,0.0002004706,0.0001092276,0.0001711133,0.0002333999,0.0002120076,0.0003957193,0.000361447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095476,"about_ca_system_score_gemma":0.0001674368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001138353,"about_ca_topic_score_gemma":0.0001980488,"domain_scores_codex":[0.9998032,0.00002833191,0.00001348505,0.00004694186,0.0000675757,0.00004049139],"domain_scores_gemma":[0.9999145,0.00001328813,0.00003805986,0.000007439578,0.000010802,0.00001580927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008843514,0.00003320435,0.00007765967,0.00005021527,0.000007269944,0.00005713691,0.000009599165,0.0002830211,0.9956194,0.0002956521,0.0001271395,0.003351435],"study_design_scores_gemma":[0.00003046213,0.0006478511,0.0002488105,0.000002583958,0.000007780911,0.0001437279,0.000003150636,0.00129967,0.9954649,0.00002713441,0.002115776,0.000008037432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446108,0.004357563,0.04355615,0.0002030818,0.0001426831,0.0002884962,0.0005206002,0.0005150434,0.00580555],"genre_scores_gemma":[0.9632964,0.001757003,0.03028478,0.0001430667,0.00002678098,0.00016514,0.0003540158,0.0000320256,0.003940915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007546767,"threshold_uncertainty_score":0.002524674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009789861047672155,"score_gpt":0.2839350697028241,"score_spread":0.274145208655152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}