{"id":"W4402099356","doi":"10.1002/anie.202414256","title":"Mirror‐Image Random Nonstandard Peptides Integrated Discovery (MI‐RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE European Research Council; Israel Cancer Research Fund; Israel Science Foundation; Japan Society for the Promotion of Science; Thompson Family Foundation; University of Toronto; National Cancer Institute; National Institutes of Health; Hebrew University of Jerusalem; National Institute of Allergy and Infectious Diseases; European Commission; United States - Israel Binational Science Foundation","keywords":"Matrix metalloproteinase; Peptide; Protease; Thioether; Amino acid; Biochemistry; Matrix (chemical analysis); Chemistry; Enzyme; Combinatorial chemistry; Stereochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003184693,0.0003315271,0.0004528041,0.0008040073,0.0001554131,0.0003105451,0.0001179294,0.000254967,0.0003913698],"category_scores_gemma":[0.0004181506,0.000289564,0.0003431567,0.0006256061,0.0002563047,0.0009144104,0.00006766526,0.0004167093,0.00003683697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003586825,"about_ca_system_score_gemma":0.0001868658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001211903,"about_ca_topic_score_gemma":0.00008930435,"domain_scores_codex":[0.9980633,0.00002544016,0.0005155377,0.0006180399,0.0004430514,0.0003346507],"domain_scores_gemma":[0.9987506,0.0002402345,0.0001348864,0.0001788996,0.0005480918,0.0001473068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001131286,0.0002224501,0.0002510884,0.0002973354,0.001085205,0.0001610868,0.0002465664,0.00000267053,0.9108441,0.001224611,0.08147378,0.003059809],"study_design_scores_gemma":[0.003029515,0.0002168042,0.00006896629,0.001537368,0.0003781036,0.0001952772,0.0006737571,0.0006068298,0.9381947,0.001672389,0.05311114,0.0003151328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8275667,0.003083301,0.1031807,0.03392635,0.001964064,0.002306644,0.005189214,0.00163121,0.02115183],"genre_scores_gemma":[0.9861858,0.0003907866,0.003377501,0.0003695661,0.0007097123,0.0003127603,0.002449131,0.00005720442,0.006147461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1586192,"threshold_uncertainty_score":0.9999557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009789861047672155,"score_gpt":0.2839350697028241,"score_spread":0.274145208655152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}