{"id":"W4402106691","doi":"10.1016/j.jaad.2024.07.1011","title":"54168 Maximum-Use Trials of Ruxolitinib Cream in Adults, Adolescents, and Children Aged 2 to &lt;12 Years With Atopic Dermatitis: Consistency of Safety, Pharmacokinetics, and Efficacy","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Atopic dermatitis; Ruxolitinib; Consistency (knowledge bases); Pharmacokinetics; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002560603,0.0007120112,0.001713899,0.000312056,0.0004021941,0.0007309407,0.0005135085,0.001058217,0.005507357],"category_scores_gemma":[0.002625431,0.0004060318,0.001480782,0.0002673405,0.0004107395,0.0009806326,0.0003562273,0.002077588,0.000883335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005433207,"about_ca_system_score_gemma":0.0004348785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006647361,"about_ca_topic_score_gemma":0.002675533,"domain_scores_codex":[0.9986014,0.0008611621,0.0001254915,0.0001382407,0.0001347641,0.0001390059],"domain_scores_gemma":[0.9989569,0.0003898286,0.0002444884,0.0001018416,0.0001204448,0.0001864987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7954744,0.01121316,0.01553547,0.001370775,0.004735712,0.0001614038,0.0002838027,0.0007141358,0.01398105,0.0003460504,0.004687467,0.1514966],"study_design_scores_gemma":[0.5736448,0.3289106,0.0741238,0.0004263037,0.002961584,0.0005350775,0.0002515345,0.0009827822,0.005464662,0.0004241091,0.01219747,0.0000771601],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807482,0.01147964,0.0003989995,0.00059725,0.0002427113,0.0008987409,0.001750447,0.00006304106,0.00382102],"genre_scores_gemma":[0.9924657,0.002717011,0.0006429098,0.0004324192,0.0001691861,0.0006321602,0.001087827,0.00001690832,0.001835778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005507357,"threshold_uncertainty_score":0.01842391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246337069297231,"score_gpt":0.2874595545873586,"score_spread":0.2749961838943863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}