{"id":"W4402106691","doi":"10.1016/j.jaad.2024.07.1011","title":"54168 Maximum-Use Trials of Ruxolitinib Cream in Adults, Adolescents, and Children Aged 2 to <12 Years With Atopic Dermatitis: Consistency of Safety, Pharmacokinetics, and Efficacy","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Atopic dermatitis; Ruxolitinib; Consistency (knowledge bases); Pharmacokinetics; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842715,0.0001055941,0.0005474054,0.0001082806,0.00001559754,0.000005561081,0.0001946423,0.000064025,0.000002613435],"category_scores_gemma":[0.00008476546,0.00007443853,0.0000924378,0.0001281856,0.0004164066,0.000007416835,0.0000596723,0.00017827,1.509757e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004466519,"about_ca_system_score_gemma":0.00005748591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003038178,"about_ca_topic_score_gemma":0.00001037667,"domain_scores_codex":[0.9986879,0.000191707,0.0007509092,0.0001337587,0.0001082127,0.0001275503],"domain_scores_gemma":[0.9991273,0.0001057352,0.0005752745,0.0000934854,0.00002743937,0.0000707802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002552111,0.0008458919,0.5157683,0.0008712995,0.001518461,0.00003925714,0.001270455,0.0001191296,0.4187128,0.0007445806,0.004899647,0.05265804],"study_design_scores_gemma":[0.001827854,0.0002043414,0.9537907,0.0005140838,0.0001523132,0.001165608,0.00006878739,0.000005050209,0.04032673,0.00005895294,0.001794868,0.00009072226],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951528,0.002448794,0.0001009597,0.001871775,0.0000216486,0.0002311015,0.0001613879,0.000001903271,0.000009593421],"genre_scores_gemma":[0.9949383,0.004018785,0.0006498279,0.0003428748,0.00002916077,0.000002224839,0.000004455392,0.0000100902,0.000004335058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4380223,"threshold_uncertainty_score":0.3035515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246337069297231,"score_gpt":0.2874595545873586,"score_spread":0.2749961838943863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}