{"id":"W4402107048","doi":"10.1016/j.jaad.2024.07.1274","title":"53695 Systemic exposure and safety profile of delgocitinib cream in adults with moderate to severe chronic hand eczema in the Phase 3 DELTA-2 trial","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada); Probity Medical Research; Queen's University","funders":"","keywords":"Medicine; Cmax; Adverse effect; Pharmacokinetics; Janus kinase inhibitor; Clinical trial; Gastroenterology; Internal medicine; Janus kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005250894,0.0001314716,0.0007913953,0.0001326575,0.00004500542,0.0000108697,0.0002035833,0.00006269805,0.00001178793],"category_scores_gemma":[0.0001765286,0.00006353873,0.00008653577,0.0004465587,0.0003735617,0.0001031023,0.00006092035,0.0007625442,7.523923e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005918322,"about_ca_system_score_gemma":0.0001534879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004607453,"about_ca_topic_score_gemma":0.00001790477,"domain_scores_codex":[0.9981999,0.0004289409,0.000756704,0.0001337978,0.0002650853,0.0002155734],"domain_scores_gemma":[0.9984738,0.0007212498,0.0006004736,0.0000808487,0.0000476167,0.00007603384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8036983,0.00283452,0.02895342,0.006646554,0.002604915,0.001808433,0.0239234,0.0009404639,0.01532357,0.0007395936,0.007463321,0.1050635],"study_design_scores_gemma":[0.4784281,0.05142548,0.06394975,0.03222443,0.004834542,0.2067267,0.03948911,0.02151101,0.04265815,0.00111327,0.05607131,0.001568192],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606488,0.007427531,0.00004677547,0.03107335,0.00005629609,0.0006033471,0.00002121534,0.000002768041,0.0001199179],"genre_scores_gemma":[0.9965272,0.002075937,0.0001451198,0.001117026,0.0001026331,0.00001380348,5.279359e-7,0.00001005859,0.000007692238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3252702,"threshold_uncertainty_score":0.3312918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02894094143996788,"score_gpt":0.3701049396946619,"score_spread":0.341163998254694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}