{"id":"W4402109144","doi":"10.1016/j.jaad.2024.07.762","title":"49513 Effectiveness and Persistence of Brodalumab in Patients with Plaque Psoriasis in the Canadian Real-World Setting: 3-Month Follow-up Results from the CARE Study","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; University of Calgary; Vancouver Coastal Health Research Institute; Ontario Tech University; Vancouver Coastal Health; Lakeridge Health; Queen's University; University of British Columbia; Guenther Dermatology Research Centre; Health Canada; University of Manitoba; Bausch Health (Canada)","funders":"","keywords":"Medicine; Persistence (discontinuity); Plaque psoriasis; Psoriasis; Dermatology; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00149773,0.0003890392,0.0008274134,0.000570655,0.001444977,0.001319531,0.000764218,0.0006666512,0.00102614],"category_scores_gemma":[0.003203736,0.0002430113,0.0009547084,0.001666842,0.0006495069,0.000476826,0.0003196433,0.0008790173,0.000174671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006974914,"about_ca_system_score_gemma":0.006952079,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6777561,"about_ca_topic_score_gemma":0.7240579,"domain_scores_codex":[0.9986621,0.000187232,0.00006954731,0.0001653265,0.0005285219,0.0003871993],"domain_scores_gemma":[0.9975981,0.0003535321,0.0005546829,0.0001152523,0.0008972607,0.0004811555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007926557,0.001053197,0.9649078,0.000154658,0.0007053624,0.0001601308,0.0003950738,0.0001974241,0.0009811056,0.00005895049,0.001114448,0.02234523],"study_design_scores_gemma":[0.0002679297,0.0007808706,0.9977213,0.00001758208,0.0002611192,0.00005545427,0.0002037015,0.0001647366,0.00009557882,0.00001038816,0.0004038729,0.00001742131],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966053,0.00140462,0.00001999939,0.0001376506,0.00001112679,0.000035382,0.0007917124,0.000005020886,0.0009891428],"genre_scores_gemma":[0.9985032,0.0004365241,0.00005838932,0.0001076376,0.00001356483,0.000008768648,0.0006624007,0.000001958506,0.0002076355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3222439,"threshold_uncertainty_score":0.6482834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258072668978344,"score_gpt":0.2546101748891541,"score_spread":0.2420294481993707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}