{"id":"W4402130292","doi":"10.3390/md22090400","title":"Novel Galectins Purified from the Sponge Chondrilla australiensis: Unique Structural Features and Cytotoxic Effects on Colorectal Cancer Cells Mediated by TF-Antigen Binding","year":2024,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology; Canadian Glycomics Network; Japan Society for the Promotion of Science; European Commission","keywords":"Sponge; Galectin; Lectin; Cytotoxic T cell; Colorectal cancer; Antigen; Biology; Cancer; Chemistry; Cancer research; Molecular biology; Biochemistry; Immunology; Genetics; In vitro; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000622078,0.0003117613,0.0001729455,0.0001972725,0.0001079354,0.0002106767,0.0001200707,0.00017708,0.0006168716],"category_scores_gemma":[0.0001162441,0.00006186533,0.0002413487,0.0001535973,0.0001455698,0.0001201059,0.0002004832,0.000271323,0.0001611249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001925594,"about_ca_system_score_gemma":0.0001263207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133956,"about_ca_topic_score_gemma":0.002356254,"domain_scores_codex":[0.9999527,0.000006329085,0.000003773979,0.00001069454,0.00001259885,0.00001382812],"domain_scores_gemma":[0.9999402,0.00000595996,0.00001371691,0.000003953041,0.0000135134,0.00002272324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004089403,0.00000561693,0.0003563339,0.0000342012,0.000004272898,0.00006793883,0.00001545197,0.0000265875,0.9981651,0.00001250399,0.00001417832,0.001256836],"study_design_scores_gemma":[0.00005407848,0.0008108311,0.07603045,0.00002173156,0.0000724715,0.002602419,0.0001760958,0.00162356,0.9084297,0.0001101019,0.01004292,0.00002566197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964656,0.001035733,0.00154063,0.0000725844,0.000009422452,0.0000208001,0.0002149565,0.00003037648,0.0006099866],"genre_scores_gemma":[0.9940701,0.0006740472,0.002609072,0.00007870913,0.00001151129,0.00001367095,0.001020752,0.00001424053,0.00150786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133956,"threshold_uncertainty_score":0.002663493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005599128374910898,"score_gpt":0.2309946509273817,"score_spread":0.2253955225524708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}