{"id":"W4402130292","doi":"10.3390/md22090400","title":"Novel Galectins Purified from the Sponge Chondrilla australiensis: Unique Structural Features and Cytotoxic Effects on Colorectal Cancer Cells Mediated by TF-Antigen Binding","year":2024,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology; Canadian Glycomics Network; Japan Society for the Promotion of Science; European Commission","keywords":"Sponge; Galectin; Lectin; Cytotoxic T cell; Colorectal cancer; Antigen; Biology; Cancer; Chemistry; Cancer research; Molecular biology; Biochemistry; Immunology; Genetics; In vitro; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434818,0.000329815,0.0003474788,0.00008937805,0.0002712859,0.00007451096,0.0002246704,0.0003807197,0.000487934],"category_scores_gemma":[0.00004180521,0.0002167816,0.00009090935,0.0002156235,0.0002054443,0.00004660955,0.0001659655,0.000692957,0.00006601807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009590611,"about_ca_system_score_gemma":0.00007932549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006393033,"about_ca_topic_score_gemma":0.0018812,"domain_scores_codex":[0.9984864,0.0001990531,0.0002098836,0.0005687416,0.00005210745,0.0004838019],"domain_scores_gemma":[0.9989418,0.0007174016,0.00007495445,0.0001962969,0.00002771538,0.00004183121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451957,0.00001628715,0.004776537,0.00002504974,0.0003711367,0.00001164426,0.0008429975,0.000001355325,0.9718204,0.00007877631,0.01696633,0.004844294],"study_design_scores_gemma":[0.0009535751,0.0002350324,0.07307286,0.00007155728,0.00008400407,0.00007645204,0.0001378745,0.000007825878,0.9008749,0.00004698762,0.02413769,0.0003013188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920197,0.002800663,0.000002144903,0.0009347808,0.002628991,0.0004394499,0.0006218742,0.0001477678,0.0004046722],"genre_scores_gemma":[0.9958521,0.0004781669,0.00001680328,0.0004306116,0.0001921201,0.00007498408,0.0005637179,0.00003627571,0.00235529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07094557,"threshold_uncertainty_score":0.9664395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005599128374910898,"score_gpt":0.2309946509273817,"score_spread":0.2253955225524708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}