{"id":"W4402134444","doi":"10.1186/s12964-024-01796-3","title":"RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression","year":2024,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Shenzhen-Hong Kong Institute of Brain Science; National Natural Science Foundation of China","keywords":"Neuroinflammation; Depression (economics); Sickness behavior; RIPK1; Inflammation; Neuroscience; Medicine; Psychology; Chemistry; Internal medicine; Necroptosis; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731492,0.0001022592,0.000111118,0.00017082,0.000124905,0.00009057199,0.0001131403,0.0000693084,0.000006936294],"category_scores_gemma":[0.00006843333,0.00009936528,0.00002609027,0.0001513251,0.00009062041,0.0003158909,0.0001134496,0.000187015,0.000001600494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001151277,"about_ca_system_score_gemma":0.00002007368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003583173,"about_ca_topic_score_gemma":0.00002063184,"domain_scores_codex":[0.9990808,0.0001864524,0.000260113,0.000242811,0.0001213179,0.0001084598],"domain_scores_gemma":[0.9993799,0.0002370994,0.00007600812,0.0002427314,0.00002138223,0.0000428828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001576068,0.00003598201,0.0002439154,0.00007937759,6.295268e-7,0.000001262438,0.001538219,0.000788687,0.9953522,0.0003731874,0.000008970839,0.001561797],"study_design_scores_gemma":[0.0003171802,0.00001586152,0.0002479275,0.0001750277,0.000005501578,0.000001923224,0.000239398,0.1022534,0.8953843,0.001256806,0.000009422534,0.00009336732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976906,0.001204668,0.0002587946,0.0001041298,0.0000173684,0.0001889623,0.000005974746,0.00006635625,0.0004631674],"genre_scores_gemma":[0.9986337,0.000844638,0.0003261813,0.00006411281,0.000003987706,0.00001862988,0.00001013265,0.00001508387,0.00008357009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1014647,"threshold_uncertainty_score":0.4051998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0337879714724181,"score_gpt":0.2659596292860787,"score_spread":0.2321716578136606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}