{"id":"W4402134444","doi":"10.1186/s12964-024-01796-3","title":"RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression","year":2024,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Shenzhen-Hong Kong Institute of Brain Science; National Natural Science Foundation of China","keywords":"Neuroinflammation; Depression (economics); Sickness behavior; RIPK1; Inflammation; Neuroscience; Medicine; Psychology; Chemistry; Internal medicine; Necroptosis; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002718447,0.0008551539,0.0008457655,0.0006082046,0.00023546,0.0002985146,0.0004760632,0.0006030575,0.001792908],"category_scores_gemma":[0.0001519306,0.0002732951,0.0006084429,0.0002321641,0.0003929414,0.0004107845,0.0002256352,0.001777117,0.000531178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003529273,"about_ca_system_score_gemma":0.0003881688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004569442,"about_ca_topic_score_gemma":0.0009261783,"domain_scores_codex":[0.9998246,0.00002289602,0.00002963827,0.00002914818,0.00003723372,0.00005658233],"domain_scores_gemma":[0.9998249,0.000008510229,0.000062705,0.00001480773,0.00002021842,0.00006885405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002181619,0.0005427629,0.0003294032,0.0002719706,0.00004191072,0.0001142367,0.00002861128,0.0001826149,0.9921107,0.0000983202,0.0003112585,0.003786703],"study_design_scores_gemma":[0.0004478192,0.005936668,0.007729159,0.00008493541,0.0001607712,0.0004623997,0.0001081374,0.002207301,0.9794402,0.0001978455,0.00320078,0.00002406882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985947,0.004924478,0.004000473,0.000720282,0.0001923735,0.0001287033,0.001843914,0.0004865716,0.001756306],"genre_scores_gemma":[0.9826562,0.004193135,0.005550382,0.0003096652,0.00005185063,0.0003429241,0.00193779,0.00006424852,0.004893726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792908,"threshold_uncertainty_score":0.005997896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0337879714724181,"score_gpt":0.2659596292860787,"score_spread":0.2321716578136606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}