{"id":"W4402135518","doi":"10.1038/s41556-024-01494-9","title":"Noncanonical inheritance of phenotypic information by protein amyloids","year":2024,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Phenotype; Inheritance (genetic algorithm); Cell biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003882946,0.0004047093,0.0003319558,0.0003548502,0.0004105847,0.0008796393,0.000402401,0.0004796218,0.001229687],"category_scores_gemma":[0.001040992,0.0003329685,0.0002179451,0.0002187337,0.0005599057,0.001046859,0.0007692248,0.001019036,0.0005688282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003049951,"about_ca_system_score_gemma":0.0001603888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001237961,"about_ca_topic_score_gemma":0.0002219074,"domain_scores_codex":[0.9997471,0.00003851094,0.00001943606,0.00005701685,0.00008323696,0.00005474056],"domain_scores_gemma":[0.9988086,0.0003376327,0.0001712761,0.000394351,0.0001417439,0.0001464376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191897,0.00002005135,0.001003228,0.00002872744,0.000008279177,0.0007134961,0.00004861926,0.0004705379,0.9832139,0.008694553,0.000322723,0.005356584],"study_design_scores_gemma":[0.00004537969,0.0001368127,0.01300296,0.00002006041,0.00003252218,0.006314121,0.0001497261,0.02834708,0.9048444,0.04145943,0.005586487,0.00006089942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788883,0.000678125,0.01550402,0.0003666931,0.00009494733,0.000005745004,0.0001209052,0.0004893041,0.003851915],"genre_scores_gemma":[0.9963727,0.0002563951,0.002039538,0.00007306557,0.00002960744,0.000006521927,0.00006954143,0.0001029521,0.001049696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001229687,"threshold_uncertainty_score":0.004113674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001856388226996928,"score_gpt":0.2210745696441533,"score_spread":0.2192181814171564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}