{"id":"W4402139826","doi":"10.3390/v16091404","title":"mRNA Vaccination: An Outlook on Innate Sensing and Adaptive Immune Responses","year":2024,"lang":"en","type":"review","venue":"Viruses","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vaccination; Immune system; Innate immune system; Immunology; Acquired immune system; Immunity; Biology; Pandemic; Virology; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007148579,0.0008453514,0.001060639,0.001334586,0.0002040002,0.0009091677,0.0007905568,0.001407225,0.002666906],"category_scores_gemma":[0.0005708378,0.000301509,0.0004605167,0.001030266,0.0005719289,0.00154894,0.0006286339,0.002501706,0.001923415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007329219,"about_ca_system_score_gemma":0.0007444698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005830884,"about_ca_topic_score_gemma":0.0009069688,"domain_scores_codex":[0.9998361,0.00003370199,0.00001678108,0.00002827182,0.00005832091,0.00002687675],"domain_scores_gemma":[0.9997637,0.000132834,0.0000229277,0.000008812475,0.00004942236,0.00002232323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001110885,0.0001075172,0.00009925055,0.01539873,0.00006624532,0.0002195725,0.00006331714,0.0006068225,0.006639469,0.01315589,0.03497132,0.9285608],"study_design_scores_gemma":[0.00001354963,0.0001220336,0.00027216,0.001743655,0.00004225743,0.000582294,0.00002729998,0.0001054237,0.0009658356,0.002531998,0.99358,0.00001348778],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001194184,0.997969,0.000225033,0.0003578531,0.0003712194,0.000003239286,0.000009852793,0.000009264266,0.0009351114],"genre_scores_gemma":[0.0007957511,0.9974686,0.0002463123,0.0003480083,0.0002424853,0.000008129039,0.00002134329,0.000002470814,0.000867074],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002666906,"threshold_uncertainty_score":0.008921742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08207611388011947,"score_gpt":0.3682548249972207,"score_spread":0.2861787111171012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}