{"id":"W4402139826","doi":"10.3390/v16091404","title":"mRNA Vaccination: An Outlook on Innate Sensing and Adaptive Immune Responses","year":2024,"lang":"en","type":"review","venue":"Viruses","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vaccination; Immune system; Innate immune system; Immunology; Acquired immune system; Immunity; Biology; Pandemic; Virology; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001533867,0.0003251524,0.0004800615,0.0001552921,0.00006554648,0.00008742088,0.0001486882,0.0002853073,0.00001675027],"category_scores_gemma":[0.00005708969,0.0002518026,0.0001585313,0.00009052432,0.00003503976,0.000006494121,0.0001453808,0.0001974101,0.0001104915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001932777,"about_ca_system_score_gemma":0.0001348825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002916301,"about_ca_topic_score_gemma":0.00002281511,"domain_scores_codex":[0.9987657,0.0001773191,0.0002905715,0.0005073309,0.00009182375,0.0001672747],"domain_scores_gemma":[0.9993671,0.00003047527,0.0001172538,0.0003700659,0.00005997198,0.0000551705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001103693,0.00002387019,0.000001068388,0.0007945953,0.0002480505,0.00004027132,0.00003453145,4.473582e-7,0.002804265,0.00005013475,0.001525154,0.9943672],"study_design_scores_gemma":[0.0000807189,0.0007251438,0.000008699446,0.002533647,0.0003289134,0.00006374581,0.00003142614,0.000006100719,0.005400484,0.00003737356,0.9904324,0.0003513378],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004503823,0.9943376,0.00001519823,0.00001124572,0.0003009146,0.0002084124,0.0001140019,0.00002376855,0.0004850939],"genre_scores_gemma":[0.001899428,0.9958864,0.00005532391,0.0002194947,0.000362565,0.00001214704,0.0001124617,0.00005116997,0.00140102],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9940159,"threshold_uncertainty_score":0.9999934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08207611388011947,"score_gpt":0.3682548249972207,"score_spread":0.2861787111171012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}