{"id":"W4402146244","doi":"10.1038/s44276-024-00077-3","title":"Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients","year":2024,"lang":"en","type":"article","venue":"BJC Reports","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Public Health Ontario; University of Toronto","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Cancer Council Victoria; Deutsche Krebshilfe; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Cancer Research Foundation in Northern Sweden; Vetenskapsrådet; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Associazione Italiana per la Ricerca sul Cancro; Imperial College London; Umeå Universitet; Bundesministerium für Bildung und Forschung; Division of Cancer Prevention, National Cancer Institute; Harvard T.H. Chan School of Public Health; National Institute for Health and Care Research; Johns Hopkins University; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Fred Hutchinson Cancer Research Center; Brigham and Women's Hospital; Emory University; World Health Organization; Cancer Research UK; American Cancer Society; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer; U.S. Department of Health and Human Services","keywords":"Calcium; Colorectal cancer; Calcium-sensing receptor; Quartile; Single-nucleotide polymorphism; Hazard ratio; Medicine; Internal medicine; Proportional hazards model; Endocrinology; Cancer; Calcium metabolism; Physiology; Gene; Biology; Genotype; Genetics; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001364539,0.0005621451,0.0008079573,0.001092013,0.0005697787,0.0009870079,0.0007348193,0.0006247605,0.001844472],"category_scores_gemma":[0.002088589,0.0005061754,0.0008225039,0.002775959,0.0003735,0.0004161778,0.0008477285,0.0006722404,0.0002994036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003329558,"about_ca_system_score_gemma":0.0004220468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01030694,"about_ca_topic_score_gemma":0.007452255,"domain_scores_codex":[0.9989027,0.000250933,0.000113766,0.000438079,0.0001552656,0.0001392495],"domain_scores_gemma":[0.9980512,0.0003290537,0.0007260307,0.0003379819,0.0001894076,0.0003664288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003622456,0.00002773196,0.9982207,0.00001901344,0.0002786936,0.00008243449,0.00008393763,0.00004278937,0.0002261534,0.00001102692,0.0001147731,0.0005303727],"study_design_scores_gemma":[0.00005326781,0.0001030182,0.9987832,0.00001231829,0.0002007166,0.0002359588,0.0001443184,0.0001199933,0.00006257858,0.00001505569,0.0002616451,0.0000078548],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975439,0.0004394294,0.0001138191,0.00002578572,0.000005823336,0.00001512767,0.001555699,0.000004764523,0.0002957649],"genre_scores_gemma":[0.9977614,0.000170045,0.00009156582,0.00002356625,0.00001221883,0.00003079756,0.001729412,0.00000523823,0.0001756903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01030694,"threshold_uncertainty_score":0.02049392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05966460352911641,"score_gpt":0.3846166225655941,"score_spread":0.3249520190364777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}