{"id":"W4402146860","doi":"10.3390/vaccines12091007","title":"Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice","year":2024,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Immunity; Immune system; Virology; Biology; Virus; Spike (software development); Nasal administration; Antibody; BETA (programming language); Immunization; Glycoprotein; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000548661,0.0003001943,0.0004172384,0.0004310588,0.00009647839,0.0001596986,0.0002128647,0.000149784,0.00003731289],"category_scores_gemma":[0.0001980818,0.0002530239,0.0001619735,0.001186666,0.00002598065,0.0003074312,0.0001303857,0.0005169316,0.0004751545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001493503,"about_ca_system_score_gemma":0.0001919502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002388473,"about_ca_topic_score_gemma":0.002081797,"domain_scores_codex":[0.99766,0.0001044246,0.0005155719,0.0006436333,0.0004216927,0.0006546645],"domain_scores_gemma":[0.9991968,0.0001075169,0.00006262579,0.0004403205,0.0001441531,0.00004862696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004331705,0.0001971474,0.04246954,0.0004480325,0.0001021234,0.0002560423,0.0004402882,0.000002870976,0.93783,0.0000757073,0.002614958,0.01513016],"study_design_scores_gemma":[0.001982925,0.00015409,0.009559802,0.0003458359,0.00005622634,0.00005096459,0.0001777743,0.01173089,0.8153813,0.0001021065,0.1601975,0.0002605756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915414,0.001661756,0.0001509472,0.002352238,0.0004473776,0.001058574,0.000008025489,0.0003486457,0.00243103],"genre_scores_gemma":[0.9872051,0.00002681206,0.00006833147,0.01159594,0.0005599096,0.000163014,0.000004397091,0.00008947909,0.0002869613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1575826,"threshold_uncertainty_score":0.9999922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05683106240752302,"score_gpt":0.3499648005340479,"score_spread":0.2931337381265249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}