{"id":"W4402147271","doi":"10.1053/j.gastro.2024.08.021","title":"Development and Validation of an Integrative Risk Score for Future Risk of Crohn’s Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Centre Hospitalier Universitaire Sainte-Justine; Dalhousie University; Queen's University; McMaster University; University of Manitoba; McGill University Health Centre; University of Ottawa; Hôpital Maisonneuve-Rosemont; Population Health Research Institute; Children's Hospital of Eastern Ontario; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; Hospital for Sick Children; Université de Montréal; University of Alberta; BC Children's Hospital; Western University; University of Toronto; Sinai Health System","funders":"Temerty Faculty of Medicine, University of Toronto; Crohn's and Colitis Canada; Canadian Association of Gastroenterology; Government of Ontario; Tel Aviv University; University of Toronto; BC Children's Hospital; University of Alberta; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Medicine; Prospective cohort study; Crohn's disease; Cohort; Disease; Framingham Risk Score; Cohort study; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005644943,0.001060526,0.0008774444,0.001208831,0.001609159,0.001290506,0.0008710374,0.001000813,0.001488002],"category_scores_gemma":[0.007548113,0.0005640303,0.0009965455,0.001050961,0.0005120856,0.0007302052,0.001245486,0.0009926812,0.0007078761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005014815,"about_ca_system_score_gemma":0.0007539094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005381047,"about_ca_topic_score_gemma":0.005086331,"domain_scores_codex":[0.9982375,0.0007508166,0.0001590785,0.0004153937,0.000272639,0.000164606],"domain_scores_gemma":[0.9967424,0.0005895264,0.0006513047,0.0008086577,0.0007324506,0.000475703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001066756,0.0004871206,0.9934897,0.00001503292,0.0002766149,0.0001672666,0.0003850884,0.0001290737,0.000790184,0.0000671212,0.0003517542,0.002774237],"study_design_scores_gemma":[0.000302655,0.001375402,0.9940162,0.0000208602,0.0003429487,0.0006922039,0.0005375473,0.001283435,0.0002351619,0.0001216315,0.00104126,0.0000308151],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977183,0.0001110598,0.0009251118,0.00004995082,0.00002496413,0.0001791712,0.0005745029,0.000007930547,0.0004090798],"genre_scores_gemma":[0.9950412,0.0001249053,0.0025071,0.00005551203,0.00004678069,0.0003062196,0.001469693,0.00001563172,0.0004330756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005644943,"threshold_uncertainty_score":0.0298537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008328796588831254,"score_gpt":0.2596475465028029,"score_spread":0.2513187499139717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}