{"id":"W4402147271","doi":"10.1053/j.gastro.2024.08.021","title":"Development and Validation of an Integrative Risk Score for Future Risk of Crohn’s Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Centre Hospitalier Universitaire Sainte-Justine; Dalhousie University; Queen's University; McMaster University; University of Manitoba; McGill University Health Centre; University of Ottawa; Hôpital Maisonneuve-Rosemont; Population Health Research Institute; Children's Hospital of Eastern Ontario; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; Hospital for Sick Children; Université de Montréal; University of Alberta; BC Children's Hospital; Western University; University of Toronto; Sinai Health System","funders":"Temerty Faculty of Medicine, University of Toronto; Crohn's and Colitis Canada; Canadian Association of Gastroenterology; Government of Ontario; Tel Aviv University; University of Toronto; BC Children's Hospital; University of Alberta; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Medicine; Prospective cohort study; Crohn's disease; Cohort; Disease; Framingham Risk Score; Cohort study; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003932614,0.0001837838,0.0002357098,0.0001159835,0.00005468585,0.00000910311,0.00009983489,0.00007748295,0.000004679776],"category_scores_gemma":[0.0001079327,0.0001570631,0.00006543813,0.00005023957,0.0001198903,0.00001567638,0.00007833346,0.0001379327,4.415973e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004870623,"about_ca_system_score_gemma":0.0001006728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003136427,"about_ca_topic_score_gemma":0.002099504,"domain_scores_codex":[0.9985133,0.0002881536,0.0004043748,0.0004858649,0.00009545575,0.0002128863],"domain_scores_gemma":[0.9993211,0.00002299671,0.00020407,0.0002268056,0.0001180432,0.0001069547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0130595,0.000469817,0.9814561,0.0001403956,0.0002758772,0.00003234308,0.003892529,0.00009060374,0.0001612038,0.00001429072,0.00001460646,0.000392739],"study_design_scores_gemma":[0.002269458,0.001522792,0.9933382,0.00005148708,0.0001225099,0.000001337377,0.001401205,0.0006495088,0.0004864202,0.0000493181,0.00002849624,0.0000792556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961354,0.0001221718,0.001379023,0.00002666335,0.0001283877,0.001900169,0.0002938871,0.000009300076,0.000005066614],"genre_scores_gemma":[0.9975446,0.0000596979,0.001704116,0.00001934182,0.00006582098,0.0004287186,0.0001483865,0.00002056416,0.000008703447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01188211,"threshold_uncertainty_score":0.6404849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008328796588831254,"score_gpt":0.2596475465028029,"score_spread":0.2513187499139717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}