{"id":"W4402170430","doi":"10.7554/elife.92707.2","title":"A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancerfonden; Barncancerfonden; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust","keywords":"Enzyme; Metabolic pathway; Cysteine; Oxidative phosphorylation; Metabolism; Biochemistry; Amino acid; Endogeny; Skeletal muscle; Biology; Cell biology; Chemistry; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970869,0.0005000748,0.0003360214,0.0002002001,0.0002165145,0.0004228431,0.0002467864,0.000358168,0.002385562],"category_scores_gemma":[0.0001546567,0.0002006467,0.0004731504,0.00009858666,0.0002928254,0.0003179789,0.00046053,0.0005340964,0.0007408956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003314467,"about_ca_system_score_gemma":0.0002217889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006537625,"about_ca_topic_score_gemma":0.001288965,"domain_scores_codex":[0.999874,0.00002476552,0.000007370276,0.00003883157,0.00002219378,0.00003279337],"domain_scores_gemma":[0.9999093,0.000009667326,0.00001977519,0.00000962769,0.00002787887,0.0000237778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006819133,0.00005680387,0.001736153,0.0001316355,0.00004505838,0.0001479117,0.00006015985,0.0003415465,0.986433,0.0004227709,0.00034627,0.009596892],"study_design_scores_gemma":[0.000322689,0.001995118,0.1159111,0.0001646172,0.0002522288,0.0007376382,0.0005828499,0.01270581,0.8294384,0.003758976,0.03405607,0.00007433449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9311873,0.01893148,0.03470661,0.001558519,0.0008582307,0.0001442144,0.001277378,0.001003704,0.01033266],"genre_scores_gemma":[0.9850335,0.003520158,0.004121926,0.0002790615,0.0001018625,0.00005799615,0.0005764482,0.00004952695,0.006259616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002385562,"threshold_uncertainty_score":0.007980466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007710193081044,"score_gpt":0.2918602564030442,"score_spread":0.2717831544722338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}