{"id":"W4402171015","doi":"10.1053/j.gastro.2024.08.031","title":"Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn’s Disease","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Hôpital Maisonneuve-Rosemont; BC Children's Hospital; McGill University Health Centre; University of Ottawa; Genome Canada; Children's Hospital of Eastern Ontario; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Calgary; University of Manitoba; Public Health Ontario; University of Toronto; Health Sciences Centre; University of Alberta","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Subclinical infection; Feces; Crohn's disease; Disease; Medicine; Multiplex; First-degree relatives; Immunology; Internal medicine; Biology; Microbiology; Family history; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499489,0.0007040882,0.0005622604,0.0009881863,0.0008985227,0.0008419253,0.0002296764,0.0004792319,0.008018925],"category_scores_gemma":[0.001650348,0.0002719637,0.0003167028,0.0007414473,0.0002803093,0.0003913331,0.000435587,0.000501456,0.0005175274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038687,"about_ca_system_score_gemma":0.0001674575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00181624,"about_ca_topic_score_gemma":0.001231781,"domain_scores_codex":[0.9997647,0.00004589346,0.0000228602,0.00006618749,0.00004822039,0.00005202503],"domain_scores_gemma":[0.9992429,0.0001416645,0.0003178371,0.00004955586,0.00004733679,0.0002007974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001066574,0.0001388118,0.970489,0.00007079409,0.0002033932,0.005018608,0.0007412866,0.00008345418,0.01393146,0.0001998046,0.0004578679,0.007598966],"study_design_scores_gemma":[0.00001760675,0.000186493,0.9812077,0.00002777443,0.0001057783,0.01533266,0.0007568224,0.000162183,0.001274355,0.0002826162,0.0006314032,0.00001454365],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988895,0.0002334147,0.0001283549,0.0000461139,0.00001374661,0.000002819361,0.0001595098,0.000008529929,0.0005180986],"genre_scores_gemma":[0.9989964,0.0001253213,0.0001445727,0.00002767646,0.0000163813,0.000003858412,0.0001364526,0.000007406961,0.0005418463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008018925,"threshold_uncertainty_score":0.0268259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697717156747345,"score_gpt":0.2611318188676511,"score_spread":0.2441546473001776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}