{"id":"W4402171015","doi":"10.1053/j.gastro.2024.08.031","title":"Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn’s Disease","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Hôpital Maisonneuve-Rosemont; BC Children's Hospital; McGill University Health Centre; University of Ottawa; Genome Canada; Children's Hospital of Eastern Ontario; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Calgary; University of Manitoba; Public Health Ontario; University of Toronto; Health Sciences Centre; University of Alberta","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Subclinical infection; Feces; Crohn's disease; Disease; Medicine; Multiplex; First-degree relatives; Immunology; Internal medicine; Biology; Microbiology; Family history; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002369566,0.0004077202,0.0004148693,0.0001357776,0.0001520564,0.0000527972,0.0002531312,0.0002629916,0.00007375338],"category_scores_gemma":[0.0004005129,0.0003779113,0.0002043673,0.00006755592,0.0006776798,0.00002556782,0.0003660712,0.0003829742,0.00001217419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005404256,"about_ca_system_score_gemma":0.0001809347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001331932,"about_ca_topic_score_gemma":0.001192101,"domain_scores_codex":[0.9973317,0.0004187551,0.000745249,0.0008152229,0.0001683348,0.0005206851],"domain_scores_gemma":[0.9986994,0.000218269,0.0002528711,0.0003982996,0.00015532,0.0002758038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01279671,0.00009923065,0.9751804,0.0003303736,0.0004131235,0.0004105711,0.0002346768,0.00005635876,0.007489128,0.000199046,0.001999797,0.0007905234],"study_design_scores_gemma":[0.001811637,0.0003883534,0.9901798,0.0001248835,0.0001633126,0.000006920831,0.00003845998,0.0005208902,0.0002616133,0.0002700719,0.005995601,0.0002385041],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945367,0.0006885881,0.001968668,0.001013684,0.0005018001,0.0003998007,0.000797603,0.00006611271,0.00002707269],"genre_scores_gemma":[0.9956053,0.0002305603,0.002456282,0.0004044498,0.0006082128,0.00007779364,0.0004762992,0.00005648192,0.00008465277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01499929,"threshold_uncertainty_score":0.9998673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697717156747345,"score_gpt":0.2611318188676511,"score_spread":0.2441546473001776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}