{"id":"W4402172464","doi":"10.1038/s41588-024-01874-9","title":"In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions","year":2024,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; National Natural Science Foundation of China; Government of Canada; Princess Margaret Cancer Foundation","keywords":"Biology; MEN1; CRISPR; Tumor microenvironment; Function (biology); In vivo; Dual function; Computational biology; Genetics; Cancer research; Cell biology; Cancer; Gene; Multiple endocrine neoplasia; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003314865,0.0006612505,0.0004265039,0.0004864272,0.0002650548,0.0006766816,0.000375303,0.0005761774,0.0028971],"category_scores_gemma":[0.000202578,0.0002672282,0.0004026729,0.0001845701,0.0004009106,0.0002141224,0.0005979574,0.000748152,0.0007315821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005369032,"about_ca_system_score_gemma":0.0003070901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007079398,"about_ca_topic_score_gemma":0.002304971,"domain_scores_codex":[0.9996278,0.00005802563,0.00004216663,0.00008477809,0.0001305131,0.00005665477],"domain_scores_gemma":[0.9996966,0.00009549856,0.00009408454,0.00003624841,0.00001681735,0.00006086413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004142082,0.00001456512,0.0001738969,0.0000249457,0.000007970076,0.00007217968,0.00001036768,0.0001630202,0.9982004,0.0001703234,0.0000482816,0.001072627],"study_design_scores_gemma":[0.000008437577,0.00007707324,0.001586219,0.000004589112,0.00001638654,0.0002529389,0.00001562014,0.001145422,0.994767,0.00006113817,0.002058898,0.000006327764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495679,0.001619257,0.03861665,0.0003388862,0.00008348627,0.0001558376,0.002947058,0.00104074,0.005630253],"genre_scores_gemma":[0.980197,0.0006413319,0.01242663,0.0001358899,0.00000741083,0.00006610066,0.0009935349,0.0001485215,0.00538372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0028971,"threshold_uncertainty_score":0.009691834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009708428185374502,"score_gpt":0.2776122853285272,"score_spread":0.2679038571431527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}