{"id":"W4402189577","doi":"10.1016/j.devcel.2024.08.007","title":"Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification","year":2024,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Montreal Clinical Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Cole Foundation; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Biology; Chromatin remodeling; Cell biology; Chromatin; Haematopoiesis; Progenitor cell; SWI/SNF; Transcription factor; Myeloid; Stem cell; Lymphopoiesis; Cellular differentiation; Enhancer; Hemangioblast; SMARCA4; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226078,0.0001764201,0.0001522312,0.00006613208,0.00006563159,0.00004472377,0.0001516979,0.00006353312,0.00005818278],"category_scores_gemma":[0.000007643753,0.0001551349,0.00003438081,0.0002881052,0.00003908153,0.000006182213,0.00007894326,0.00004790754,0.00004278011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007579639,"about_ca_system_score_gemma":0.0003141325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000436324,"about_ca_topic_score_gemma":0.00004770095,"domain_scores_codex":[0.9989663,0.00001738573,0.000280247,0.0003585714,0.0001822734,0.0001952571],"domain_scores_gemma":[0.9995599,0.000007189106,0.00005602026,0.0001729589,0.0001265136,0.00007746858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006600794,0.00004884977,0.000367334,0.0001934569,0.00003369657,0.000002910052,0.0003524705,0.0007682121,0.9925462,0.00001211139,0.0009179181,0.00469081],"study_design_scores_gemma":[0.0003358343,0.0001548348,0.0005440729,0.0001638451,0.00001339959,0.00003215656,0.0002542095,0.002210267,0.974749,0.00001869002,0.02127818,0.0002454784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933342,0.0008880356,0.002380313,0.00007674971,0.00009759717,0.0002665956,0.00004448744,0.00003820713,0.002873805],"genre_scores_gemma":[0.96908,0.00009887122,0.02912966,0.00007201134,0.00009337968,0.00002566572,0.0003159842,0.00003746799,0.001146961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02674935,"threshold_uncertainty_score":0.6326219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053383899959465,"score_gpt":0.23290557761522,"score_spread":0.2223717386156253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}