{"id":"W4402192295","doi":"10.2174/0115665232294935240826061311","title":"Recent Advances in Therapeutics and Manufacturing Processes of Recombinant Adeno-Associated Virus for the Treatment of Lung Diseases","year":2024,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Feldan (Canada)","funders":"","keywords":"Genetic enhancement; Cystic fibrosis; Medicine; Lung; Gene delivery; Adeno-associated virus; Clinical trial; Immunology; Disease; Bioinformatics; Recombinant DNA; Biology; Vector (molecular biology); Gene; Pathology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002058171,0.000444514,0.0009249423,0.0001356605,0.00005931594,0.00002325508,0.0003330479,0.0001637351,0.000006790367],"category_scores_gemma":[0.00001700674,0.0002599142,0.0003265814,0.0002093757,0.0001349276,0.000005126833,0.00004658976,0.0001157239,5.614536e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009263178,"about_ca_system_score_gemma":0.0004481783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002901907,"about_ca_topic_score_gemma":0.00008490571,"domain_scores_codex":[0.9982282,0.0001780069,0.0005799758,0.0004960588,0.0001933105,0.0003244532],"domain_scores_gemma":[0.9989042,0.0001580816,0.0003433696,0.0004307104,0.000110625,0.00005296976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000636834,0.0007369329,0.00002013898,0.004902998,0.0006927996,6.161437e-7,0.00009560772,0.000005443267,0.0003892626,6.397427e-7,0.00004674778,0.992472],"study_design_scores_gemma":[0.0009300776,0.003146036,0.000008201857,0.001680797,0.0005224568,0.000001616325,0.00001434969,0.000008435286,0.03660711,0.0000618854,0.9567581,0.0002609297],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01069506,0.9862581,0.000009087129,0.00002292134,0.0005393646,0.002031535,0.0004331434,0.000008948914,0.000001812028],"genre_scores_gemma":[0.0004444421,0.998126,0.000005970965,0.00000704044,0.0001660804,0.0007317165,0.0003931279,0.00007817908,0.00004739892],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.992211,"threshold_uncertainty_score":0.9999853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07757918336534553,"score_gpt":0.4116906513443414,"score_spread":0.3341114679789959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}