{"id":"W4402196330","doi":"10.1016/j.actbio.2024.08.053","title":"Lipopolymer/siRNA complexes engineered for optimal molecular and functional response with chemotherapy in FLT3-mutated acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates - Technology Futures; Natural Sciences and Engineering Research Council of Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Myeloid leukemia; Cancer research; Materials science; Chemotherapy; Leukemia; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453889,0.0002699837,0.0001999277,0.0001356182,0.00008565788,0.0002347376,0.0001547157,0.0002927199,0.0006542357],"category_scores_gemma":[0.0001391152,0.0001074663,0.0001424803,0.0001274806,0.0001385772,0.0001504196,0.000155402,0.0002939101,0.0003066872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003255302,"about_ca_system_score_gemma":0.0001515084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005685331,"about_ca_topic_score_gemma":0.0006452331,"domain_scores_codex":[0.9998883,0.00002385279,0.00001254537,0.00002453235,0.00002980579,0.00002095376],"domain_scores_gemma":[0.9999471,0.00001219326,0.00001735161,0.000004660052,0.000008943454,0.00000978515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009059624,0.0000189813,0.00003130346,0.00002726717,0.000003209999,0.00002368057,0.000008248351,0.0001291919,0.9983006,0.00005844816,0.0000295128,0.001279025],"study_design_scores_gemma":[0.00002654022,0.0003229713,0.0005323521,0.000002709742,0.0000126655,0.00009692532,0.000004759874,0.001189218,0.9965801,0.00001672656,0.001211385,0.000003607251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913772,0.001453952,0.005509836,0.00007912288,0.00002337236,0.00008571148,0.0001557371,0.00009156732,0.00122341],"genre_scores_gemma":[0.9936846,0.0005927845,0.003936952,0.00004472407,0.000005578268,0.00005949528,0.0001900796,0.00002432533,0.001461505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006542357,"threshold_uncertainty_score":0.002361894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348089768754061,"score_gpt":0.2794710668300208,"score_spread":0.2659901691424802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}