{"id":"W4402207940","doi":"10.1093/pnasnexus/pgae381","title":"Subclass IId bacteriocins targeting mannose phosphotransferase system—Structural diversity and implications for receptor interaction and antimicrobial activity","year":2024,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Narodowa Agencja Wymiany Akademickiej; Narodowe Centrum Nauki; Fundacja na rzecz Nauki Polskiej; University of Alberta","keywords":"Bacteriocin; Subclass; Biology; Antimicrobial peptides; Mannose; Receptor; Computational biology; Amino acid residue; Peptide sequence; Antimicrobial; Biochemistry; Microbiology; Antibody; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009790026,0.0001502779,0.0001839685,0.0004293272,0.00009696558,0.0004006369,0.0001624346,0.0002140748,0.0005488688],"category_scores_gemma":[0.0001393614,0.00005607208,0.000196329,0.000298741,0.0001625641,0.0001353738,0.0002245878,0.000209308,0.0002087394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483115,"about_ca_system_score_gemma":0.0001160356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005371638,"about_ca_topic_score_gemma":0.0002658787,"domain_scores_codex":[0.9999396,0.000008728211,0.000006586603,0.00001576941,0.00001187083,0.00001741189],"domain_scores_gemma":[0.9998754,0.00001372961,0.00003384346,0.00001068925,0.0000192995,0.0000469942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002449971,0.00002992913,0.00884298,0.00003116007,0.0000118382,0.0002178054,0.00004410084,0.0001305389,0.9863159,0.0002304592,0.00006056272,0.003839597],"study_design_scores_gemma":[0.0001278397,0.0013613,0.4009052,0.00004741997,0.0001653247,0.009188934,0.000741205,0.009971926,0.5634066,0.001877292,0.0121566,0.00005033447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977329,0.0007108106,0.0007796292,0.00004233951,0.000005841194,0.000006485245,0.00008081057,0.0000104644,0.0006307413],"genre_scores_gemma":[0.9983757,0.0002364682,0.0007721244,0.00003684486,0.000009124858,0.000005063398,0.0002219636,0.000003477923,0.0003391844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005488688,"threshold_uncertainty_score":0.001836181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923769580766021,"score_gpt":0.2348218673849453,"score_spread":0.2155841715772851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}