{"id":"W4402217758","doi":"10.1073/pnas.2321794121","title":"Inherited human RelB deficiency impairs innate and adaptive immunity to infection","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Neurological Disorders and Stroke; Faculty of Medicine and Health, University of Sydney; National Center for Advancing Translational Sciences; Medical Research Council; National Cancer Institute; HORIZON EUROPE Framework Programme; National Institutes of Health; New South Wales Government; Honjo International Scholarship Foundation; Universidad de Antioquia; European Society for Immunodeficiencies; Hospital for Sick Children; Stavros Niarchos Foundation; European Commission; Assistance Publique - Hôpitaux de Paris; Medizinische Universität Wien; University of New South Wales; National Health and Medical Research Council; Cancer Research Institute; Lastentautien Tutkimussäätiö; Institut des maladies génétiques Imagine; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Australian Government; Institut National de la Santé et de la Recherche Médicale; Department of Health and Aged Care, Australian Government; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Fondation du Souffle; Science for Life Laboratory; Rockefeller University; Österreichischen Akademie der Wissenschaften; Uppsala Universitet; St. Giles Foundation; Fulbright U.S. Scholar Program; Fondation pour la Recherche Médicale; Universität Wien; Howard Hughes Medical Institute","keywords":"RELB; Biology; Immunology; Immunoglobulin class switching; Antibody; B cell; Cancer research; Virology; NFKB1; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009136934,0.00006890482,0.00006764221,0.0001230941,0.0001683272,0.0000272637,0.0002461879,0.00007396954,0.000002278287],"category_scores_gemma":[0.0002582473,0.00005003457,0.00003849931,0.0005461152,0.0003838767,0.00002189473,0.0001830196,0.000109436,6.32243e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000150031,"about_ca_system_score_gemma":0.00002884884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002718094,"about_ca_topic_score_gemma":3.851832e-7,"domain_scores_codex":[0.9991859,0.000007269239,0.0001641484,0.0002092425,0.0003366144,0.00009681857],"domain_scores_gemma":[0.9996923,0.00001643747,0.00008897913,0.000007446362,0.0001684553,0.00002635979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007744925,0.00001412255,0.00195801,0.00003298805,0.000007360356,3.282608e-9,0.0001435331,0.00003517808,0.9863949,0.01086123,0.0002664602,0.0002785043],"study_design_scores_gemma":[0.00006595531,0.000248398,0.04868172,0.00009937806,0.00000812728,0.000009300754,0.00008691349,0.0002658858,0.9368469,0.01311086,0.0004930261,0.00008351525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968283,0.0003201706,0.00000820117,0.0005443795,0.00001854568,0.0001120638,0.000009764835,0.00001013769,0.002148477],"genre_scores_gemma":[0.9992774,0.00002441283,0.0004367487,0.0001341392,0.00004665849,0.0000072433,3.176435e-7,0.000003928696,0.00006918657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04954795,"threshold_uncertainty_score":0.2040351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106291288633077,"score_gpt":0.3168154898121556,"score_spread":0.2757525769258248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}