{"id":"W4402217758","doi":"10.1073/pnas.2321794121","title":"Inherited human RelB deficiency impairs innate and adaptive immunity to infection","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Neurological Disorders and Stroke; Faculty of Medicine and Health, University of Sydney; National Center for Advancing Translational Sciences; Medical Research Council; National Cancer Institute; HORIZON EUROPE Framework Programme; National Institutes of Health; New South Wales Government; Honjo International Scholarship Foundation; Universidad de Antioquia; European Society for Immunodeficiencies; Hospital for Sick Children; Stavros Niarchos Foundation; European Commission; Assistance Publique - Hôpitaux de Paris; Medizinische Universität Wien; University of New South Wales; National Health and Medical Research Council; Cancer Research Institute; Lastentautien Tutkimussäätiö; Institut des maladies génétiques Imagine; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Australian Government; Institut National de la Santé et de la Recherche Médicale; Department of Health and Aged Care, Australian Government; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Fondation du Souffle; Science for Life Laboratory; Rockefeller University; Österreichischen Akademie der Wissenschaften; Uppsala Universitet; St. Giles Foundation; Fulbright U.S. Scholar Program; Fondation pour la Recherche Médicale; Universität Wien; Howard Hughes Medical Institute","keywords":"RELB; Biology; Immunology; Immunoglobulin class switching; Antibody; B cell; Cancer research; Virology; NFKB1; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097369,0.00116211,0.0002921055,0.0004125336,0.0003026908,0.000259546,0.0002040509,0.0007005623,0.001999184],"category_scores_gemma":[0.0002956568,0.0002436853,0.000234118,0.0001559285,0.0002754574,0.000175269,0.000308081,0.0004494504,0.0004574585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188145,"about_ca_system_score_gemma":0.00009901271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003800738,"about_ca_topic_score_gemma":0.0002929094,"domain_scores_codex":[0.9998848,0.00001561172,0.00001568141,0.00004374221,0.00001774846,0.00002223894],"domain_scores_gemma":[0.9998388,0.0000256226,0.00006071046,0.00001229777,0.000009894428,0.00005264846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00210871,0.0004842453,0.05189666,0.0002321721,0.000138613,0.172693,0.000879916,0.0002875582,0.7461244,0.0008476546,0.001063685,0.02324336],"study_design_scores_gemma":[0.0002843056,0.001840068,0.1885219,0.00006477272,0.00018962,0.7311237,0.0003026257,0.0008924279,0.07080211,0.0003971308,0.005540506,0.00004084237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982309,0.0005610067,0.0004900417,0.00006566303,0.000009990073,0.000008854799,0.0001291973,0.00005591407,0.0004484509],"genre_scores_gemma":[0.9985479,0.0003204517,0.000293056,0.0000415381,0.00001524887,0.000007055132,0.0001212676,0.00001310224,0.0006404197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999184,"threshold_uncertainty_score":0.00668788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106291288633077,"score_gpt":0.3168154898121556,"score_spread":0.2757525769258248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}