{"id":"W4402225711","doi":"10.1016/j.jmb.2024.168779","title":"Pause Patrol: Negative Elongation Factor’s Role in Promoter-Proximal Pausing and Beyond","year":2024,"lang":"en","type":"review","venue":"Journal of Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Howard Hughes Medical Institute","keywords":"RNA polymerase II; Elongation factor; Transcription (linguistics); Biology; Transcription factor; Transcription factor II F; Promoter; Cell biology; Transcription factor II E; Transcription factor II D; Molecular biology; RNA; Gene; Transcriptional regulation; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001077325,0.001376651,0.001819052,0.001493528,0.0003085348,0.001382222,0.001317991,0.002040246,0.00263869],"category_scores_gemma":[0.001003027,0.0005469243,0.0004710466,0.001720051,0.001116165,0.001984266,0.001029877,0.003617826,0.00314885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009631311,"about_ca_system_score_gemma":0.001254053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008243133,"about_ca_topic_score_gemma":0.001631505,"domain_scores_codex":[0.9998173,0.00002525047,0.00002694993,0.00004194526,0.00006253612,0.00002595076],"domain_scores_gemma":[0.999586,0.0002139973,0.00004736556,0.00001707899,0.00008717079,0.00004829903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002523639,0.00005926305,0.0001379956,0.009337429,0.00009932647,0.0002348486,0.00004916314,0.0004989157,0.003904009,0.009599287,0.06326289,0.9125645],"study_design_scores_gemma":[0.00004396637,0.00007962406,0.0004205442,0.001789563,0.00008034167,0.0005750279,0.00003045319,0.00008691306,0.0008430707,0.003795253,0.9922322,0.00002319653],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005441513,0.9983196,0.0001576035,0.0003840094,0.0005157354,0.000002109996,0.00001368455,0.00000760194,0.0005451138],"genre_scores_gemma":[0.0005368633,0.9972631,0.0001970935,0.0005513129,0.0005925617,0.000006917684,0.00003860597,0.000002991724,0.0008105614],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00263869,"threshold_uncertainty_score":0.008827329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020030932606278,"score_gpt":0.3482268422070372,"score_spread":0.3280265328809744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}