{"id":"W4402230058","doi":"10.1021/acs.chemrestox.4c00225","title":"Omeprazole-Associated Atypical Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Patient with Positive In Vitro Diagnostic Testing to Multiple Proton Pump Inhibitors","year":2024,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; AstraZeneca","keywords":"Omeprazole; Medicine; Drug; Proton-pump inhibitor; Eosinophilia; Hypersensitivity reaction; Immunology; Adverse drug reaction; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000365617,0.001054601,0.0008900448,0.001038288,0.001081542,0.0007349786,0.0005291646,0.002881902,0.001569364],"category_scores_gemma":[0.002036966,0.0006519544,0.0007142876,0.0005330098,0.0008453187,0.0009438588,0.0007173803,0.002201836,0.0004465218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006207018,"about_ca_system_score_gemma":0.0004734243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001448722,"about_ca_topic_score_gemma":0.001985198,"domain_scores_codex":[0.9995152,0.00009448149,0.00005827684,0.0001151078,0.0000741535,0.0001428038],"domain_scores_gemma":[0.9990342,0.0003007534,0.0001787327,0.00005750971,0.00006831922,0.0003605064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00009315951,0.00009403667,0.01827098,0.00004862394,0.00001638208,0.9776749,0.0002121926,0.00006667105,0.00163753,0.000104551,0.0002386453,0.001542391],"study_design_scores_gemma":[0.00002992789,0.000408562,0.02417542,0.00002463642,0.00003665093,0.9732454,0.0001436233,0.0003905684,0.0008634764,0.0000877216,0.0005782216,0.00001567403],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843609,0.003177887,0.002404993,0.002494478,0.0002702724,0.0002023699,0.0001274469,0.0001221678,0.006839532],"genre_scores_gemma":[0.9976708,0.0006036109,0.0003847379,0.000646625,0.0001986178,0.00001006387,0.00003215798,0.000007051786,0.0004464087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002881902,"threshold_uncertainty_score":0.005250037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331679875451596,"score_gpt":0.3324064718590714,"score_spread":0.2990896731045555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}