{"id":"W4402231607","doi":"10.1021/acsabm.4c00901","title":"Injectable and 3D Extrusion Printable Hydrophilic Silicone-Based Hydrogels for Controlled Ocular Delivery of Ophthalmic Drugs","year":2024,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"Hydrogels: synthesis, properties, applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Self-healing hydrogels; Silicone; Silicone hydrogel; Extrusion; Silicone oil; Materials science; Elastomer; Silicone Elastomers; Polymer; Viscosity; 3D printing; Polymer science; Interpenetrating polymer network; Polymer chemistry; Composite material; Ophthalmology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009599919,0.0002428123,0.00008102093,0.0001361074,0.00005441719,0.0001313152,0.00009598509,0.0001379459,0.0006673021],"category_scores_gemma":[0.00008434607,0.0001054087,0.0001467326,0.00007274257,0.0001200502,0.0002066023,0.0001503384,0.0002206021,0.0001899185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286287,"about_ca_system_score_gemma":0.0001145818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001522034,"about_ca_topic_score_gemma":0.0004955135,"domain_scores_codex":[0.9999518,0.000004859889,0.000004362297,0.000008493746,0.00002128827,0.000009107829],"domain_scores_gemma":[0.9999435,0.00001521667,0.00002409463,0.000005330984,0.000004162824,0.00000765394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009373614,0.000004969765,0.00002681873,0.00002580067,0.000001068521,0.0000257531,0.000006853646,0.00009541804,0.9977502,0.0000560243,0.00001915587,0.001978513],"study_design_scores_gemma":[0.000002931167,0.00005117781,0.0004635185,0.000002514329,0.000003874096,0.00006778904,0.000004905955,0.0009925999,0.9972065,0.00001609102,0.001183806,0.000004090854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961827,0.003929313,0.02975055,0.0001077508,0.00009261202,0.00005915125,0.0003346544,0.0002432214,0.003655634],"genre_scores_gemma":[0.9740261,0.001755411,0.02073188,0.00006998992,0.00002142458,0.00003538649,0.0001206465,0.000044125,0.003194977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006673021,"threshold_uncertainty_score":0.002232373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065662567272763,"score_gpt":0.2331501097331663,"score_spread":0.2224934840604386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}