{"id":"W4402266270","doi":"10.1158/1538-7445.pediatric24-b024","title":"Abstract B024: Single cell transcriptomics and patient-derived tumoroids reveal that hepatobiliary lineage programs cooperate with Wnt pathway mutations to drive cell proliferation in hepatoblastoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Liver physiology and pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Hepatoblastoma; Wnt signaling pathway; Lineage (genetic); Cancer research; Cell growth; Biology; Transcriptome; Cell; Genetics; Gene; Medicine; Computational biology; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003547392,0.0001936864,0.0002910708,0.0002967702,0.0001418945,0.00007480665,0.00008901968,0.0001527103,0.00005146649],"category_scores_gemma":[0.00001844719,0.0001526279,0.00003937553,0.0005690589,0.0002813743,0.0001695319,0.00004711827,0.0007845621,0.0000374561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000216367,"about_ca_system_score_gemma":0.0006571513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002666293,"about_ca_topic_score_gemma":0.0006765096,"domain_scores_codex":[0.9981361,0.0002121019,0.0002583178,0.0005835123,0.0003007,0.0005092629],"domain_scores_gemma":[0.9991556,0.0001211397,0.00002827014,0.0002115457,0.0002512189,0.000232181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001184543,0.0004868071,0.01444612,0.0006300674,0.00002431272,0.000848941,0.01317691,0.0001458502,0.9628766,0.00002042416,0.0002280254,0.005931417],"study_design_scores_gemma":[0.00163489,0.004316673,0.02125704,0.0007287926,0.00003309385,0.00006037084,0.001805922,0.0009795412,0.9680571,0.00006013976,0.0007885566,0.000277885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955821,0.00114652,0.00004225911,0.0007239826,0.0001311083,0.00186767,0.00005971522,0.00007064777,0.0003760218],"genre_scores_gemma":[0.998064,0.0001480972,0.0002629926,0.0002470494,0.0001063952,0.000735624,0.0001099623,0.00004589358,0.0002799655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01137099,"threshold_uncertainty_score":0.6223986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05140030899510943,"score_gpt":0.3230184479166602,"score_spread":0.2716181389215508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}