{"id":"W4402266328","doi":"10.1158/1538-7445.pediatric24-a060","title":"Abstract A060 Investigating underlying efficacy and mechanism of action of the KIF11 inhibitor filanesib in Ewing and clear cell sarcomas","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Mechanism of action; Mechanism (biology); Action (physics); Sarcoma; Cancer research; Biology; Pathology; Genetics; Epistemology; Philosophy; Physics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002799218,0.0004021199,0.0004836642,0.0003871043,0.0001992507,0.0004947918,0.000266989,0.0003828974,0.005000348],"category_scores_gemma":[0.0001663099,0.0001150577,0.0004657491,0.0002479328,0.000160987,0.0003682411,0.000164169,0.000830887,0.000986894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000536827,"about_ca_system_score_gemma":0.0004933301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125143,"about_ca_topic_score_gemma":0.002006839,"domain_scores_codex":[0.999882,0.00001652588,0.00001089368,0.00001570144,0.00003687783,0.00003805619],"domain_scores_gemma":[0.999903,0.00001871373,0.00001847492,0.000006391482,0.00002461781,0.00002875214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003967724,0.001626024,0.002172593,0.0006091005,0.0001023299,0.0002701653,0.00004281421,0.00131724,0.9368606,0.0005526536,0.002467916,0.05001079],"study_design_scores_gemma":[0.001100278,0.02800313,0.02187756,0.00006268399,0.0002741802,0.001092632,0.0001450944,0.004253671,0.9196096,0.0003218003,0.02322155,0.00003781577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716417,0.01411224,0.001440776,0.0007027708,0.0001709279,0.000310482,0.002841771,0.0001981047,0.008581288],"genre_scores_gemma":[0.9866196,0.004346266,0.0007569061,0.0002141619,0.0000433876,0.0001040104,0.002591904,0.00001318996,0.005310526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005000348,"threshold_uncertainty_score":0.01672786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2172791282426156,"score_gpt":0.4375576609352697,"score_spread":0.220278532692654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}