{"id":"W4402266499","doi":"10.1158/1538-7445.pediatric24-b049","title":"Abstract B049: Oncolytic HSV1716-GMCSF combination strategies to remodel the immunosuppressive osteosarcoma tumor-microenvironment and promote anti-tumor immunity","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Oncolytic virus; Osteosarcoma; Tumor microenvironment; Medicine; Immunity; Cancer research; Immunology; Immune system; Tumor cells","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008201116,0.0003745747,0.0002649237,0.0002904808,0.00008528622,0.0002341162,0.0001733247,0.0002483435,0.001497137],"category_scores_gemma":[0.00003958929,0.00008119581,0.0002070716,0.0001627505,0.0001295563,0.0001466753,0.0001523168,0.0005042143,0.0004543967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002237293,"about_ca_system_score_gemma":0.0002680363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005367159,"about_ca_topic_score_gemma":0.0007837247,"domain_scores_codex":[0.9999286,0.000008996875,0.000006082634,0.000009118698,0.0000260926,0.00002110135],"domain_scores_gemma":[0.9999743,0.000002258185,0.000006586605,0.000002726295,0.000004181868,0.00001002867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004564293,0.0001955265,0.0001803614,0.0001082204,0.00001252146,0.00004903389,0.0000120796,0.0002637332,0.9899473,0.0002020326,0.0002927611,0.008279968],"study_design_scores_gemma":[0.00009174785,0.00174092,0.001346244,0.00001371808,0.00003933709,0.0002803383,0.00002018892,0.001166348,0.9868694,0.0000684484,0.008358064,0.000005281199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848518,0.005865938,0.004073467,0.0001845544,0.0001502567,0.000167541,0.0007206458,0.00014342,0.00384223],"genre_scores_gemma":[0.9885781,0.002139876,0.00449575,0.00006920163,0.00002514728,0.0001061277,0.0005784861,0.00002648637,0.003980913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497137,"threshold_uncertainty_score":0.005008459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03407052938666342,"score_gpt":0.3708689670075334,"score_spread":0.3367984376208699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}