{"id":"W4402266523","doi":"10.1158/1538-7445.pediatric24-a064","title":"Abstract A064 Characterizing the immune microenvironment and examining the effect of tumour-targeted MRgHIFU mediated hyperthermia in combination with thermosensitive liposomal doxorubicin in a mouse model of embryonal rhabdomyosarcoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Doxorubicin; Rhabdomyosarcoma; Cancer research; Embryonal rhabdomyosarcoma; Immune system; Tumor microenvironment; Medicine; Immunology; Internal medicine; Sarcoma; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074706,0.0004628687,0.0003471386,0.0004248321,0.0001276481,0.0001758379,0.0001960703,0.0004424259,0.001529591],"category_scores_gemma":[0.00005520007,0.0001468936,0.0004388748,0.0001263989,0.0003203548,0.0002510501,0.0001208735,0.0007362626,0.000329207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084686,"about_ca_system_score_gemma":0.0001681268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005665001,"about_ca_topic_score_gemma":0.0007102212,"domain_scores_codex":[0.9998115,0.00002263364,0.00001834407,0.00004913077,0.00005286856,0.00004548544],"domain_scores_gemma":[0.9998928,0.00001122422,0.00003627818,0.00001320779,0.0000122139,0.0000343301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005227412,0.0001691102,0.0001695981,0.00003730668,0.000004598045,0.00003083352,0.00001194494,0.00008178041,0.997741,0.00004717139,0.00004637926,0.001137573],"study_design_scores_gemma":[0.00006135488,0.004730418,0.003072501,0.000007222491,0.00002423269,0.0001379045,0.00002799807,0.0008856941,0.9897585,0.00002642318,0.001261236,0.000006642905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930948,0.001164079,0.003272623,0.0001194958,0.00007036161,0.0001815364,0.0007124929,0.0001236696,0.001260995],"genre_scores_gemma":[0.9867043,0.00101213,0.004726407,0.0001003796,0.00002987295,0.0003394923,0.0007737572,0.00002302956,0.006290611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529591,"threshold_uncertainty_score":0.005117059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335336103769013,"score_gpt":0.3071696772681062,"score_spread":0.2736360668912049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}