{"id":"W4402266537","doi":"10.1158/1538-7445.pediatric24-a006","title":"Abstract A006 Targeting boundary cap cells leads to mouse <i>Smarcb1</i>-deficient peripheral nerve tumors recapitulating human peripheral rhabdoid tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Peripheral; SMARCB1; Pathology; Cancer research; Medicine; Peripheral nerve; Biology; Anatomy; Internal medicine; Genetics; Transcription factor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001204871,0.0003519206,0.000305388,0.0001699425,0.0006947893,0.0004964613,0.0005229909,0.0001905678,0.0004595595],"category_scores_gemma":[0.00007847949,0.000342352,0.0002235548,0.0004380938,0.0002587426,0.00001613846,0.000358712,0.0007934307,0.00004108557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005611581,"about_ca_system_score_gemma":0.0007971494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001683284,"about_ca_topic_score_gemma":0.0003782428,"domain_scores_codex":[0.9962778,0.0001642823,0.0005315433,0.001075994,0.0007989745,0.001151368],"domain_scores_gemma":[0.9986897,0.00003268936,0.00006213055,0.0005564385,0.0003153387,0.0003436917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007145805,0.00004433913,0.0002329125,0.0003566521,0.0000370183,0.00005353501,0.001228125,0.01200276,0.9673446,0.00002539971,0.01632775,0.002275483],"study_design_scores_gemma":[0.0004199544,0.0003721793,0.0002638971,0.0005666218,0.00001196299,0.0000168265,0.001143265,0.00164068,0.9589061,0.0000591846,0.03593279,0.0006665345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882419,0.008556913,0.0001090379,0.0004878821,0.0004525022,0.0004541465,0.0001130651,0.0001002176,0.001484399],"genre_scores_gemma":[0.9914817,0.0001780049,0.0004441617,0.00020453,0.00146982,0.0002324546,0.0001486375,0.0001416057,0.005699084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01960504,"threshold_uncertainty_score":0.9999028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374299853257327,"score_gpt":0.3585304501562639,"score_spread":0.3247874516236906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}