{"id":"W4402266600","doi":"10.1158/1538-7445.pediatric24-a058","title":"Abstract A058 Response of neuroblastoma patient-derived xenografts to cyclophosphamide + topotecan enables identification of gene expression patterns associated with drug resistance","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Topotecan; Cyclophosphamide; Neuroblastoma; Identification (biology); Medicine; Drug resistance; Cancer research; Drug; Gene; Pharmacology; Oncology; Biology; Internal medicine; Chemotherapy; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240213,0.0001375624,0.0002035032,0.000209269,0.000105742,0.000253329,0.00007380161,0.0001120525,0.001555654],"category_scores_gemma":[0.0001390025,0.0000622858,0.000177696,0.0002076149,0.00007944859,0.00006672365,0.00008586528,0.0002411645,0.0003231828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001571423,"about_ca_system_score_gemma":0.0001258952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008664403,"about_ca_topic_score_gemma":0.0008673234,"domain_scores_codex":[0.9998988,0.00001375572,0.000009898193,0.00002625272,0.00003306643,0.00001822174],"domain_scores_gemma":[0.9999334,0.00002329743,0.00001183398,0.00000746008,0.00001197761,0.00001220988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006294806,0.00009155535,0.01077954,0.00002860248,0.00001613559,0.00004976241,0.00002925599,0.0004534256,0.9845116,0.00005166454,0.0001518001,0.00320708],"study_design_scores_gemma":[0.00005750874,0.002631587,0.2673966,0.00001090405,0.0000679713,0.000822087,0.0001899799,0.01305083,0.7121763,0.00009526499,0.003488842,0.00001210971],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978454,0.0001336281,0.0005733604,0.000009460929,0.000004673718,0.00001476253,0.001087743,0.00001433764,0.0003165972],"genre_scores_gemma":[0.9942486,0.0001427938,0.001506121,0.00001366835,0.000002379507,0.00004068489,0.002944135,0.000006651439,0.001095081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555654,"threshold_uncertainty_score":0.005204201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277745145107931,"score_gpt":0.3440732913234072,"score_spread":0.3162987768126141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}