{"id":"W4402266752","doi":"10.1158/1538-7445.pediatric24-pr011","title":"Abstract PR011: Alectinib in children and adolescents with solid or CNS tumors harboring ALK-fusions: Updated data from the iMATRIX Alectinib phase I/II open-label, multi-center study","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Alectinib; Medicine; Center (category theory); Solid tumor; Oncology; Internal medicine; Cancer; Crizotinib; Chemistry; Lung cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002181315,0.0004210881,0.0008764009,0.0003932079,0.0001453791,0.0008530384,0.0004377509,0.0003214228,0.001560995],"category_scores_gemma":[0.00233273,0.0001931089,0.001048043,0.0009980239,0.0001782585,0.0005088557,0.0003355873,0.0008683086,0.0003331038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004356135,"about_ca_system_score_gemma":0.0009716584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132719,"about_ca_topic_score_gemma":0.002585036,"domain_scores_codex":[0.9990108,0.0004092944,0.0001557286,0.0001327253,0.0002262726,0.00006515252],"domain_scores_gemma":[0.9970558,0.0006939999,0.001500969,0.0001301639,0.0003668342,0.0002523733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1549144,0.001544237,0.4918703,0.006035643,0.009312619,0.001072996,0.0002721397,0.003102515,0.01720973,0.0003583351,0.03622973,0.2780773],"study_design_scores_gemma":[0.03402223,0.02471775,0.869195,0.0009370976,0.0114748,0.003595493,0.0001920433,0.001389583,0.006551567,0.0002087261,0.04762445,0.00009127962],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8935757,0.04407047,0.001787543,0.001280456,0.0001715471,0.0009813197,0.05081286,0.0001815708,0.007138624],"genre_scores_gemma":[0.9271294,0.01285563,0.00231163,0.0008224174,0.0001992155,0.0005453267,0.05478182,0.00004283853,0.001311629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002181315,"threshold_uncertainty_score":0.01153606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1832606208784122,"score_gpt":0.5303666304707177,"score_spread":0.3471060095923055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}