{"id":"W4402266764","doi":"10.1158/1538-7445.pediatric24-a001","title":"Abstract A001: PAX3-FOXO1-induced transcriptional dysregulation in rhabdomyosarcoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PAX3; FOXO1; Cancer research; Rhabdomyosarcoma; Medicine; Alveolar rhabdomyosarcoma; Biology; Genetics; Transcription factor; Gene; Sarcoma; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290915,0.0002096649,0.0001340077,0.0002433593,0.0001694351,0.0001915376,0.000137629,0.0002293722,0.003782055],"category_scores_gemma":[0.0000759238,0.00009294434,0.0002240807,0.0001477819,0.0003227699,0.000118402,0.0002044003,0.0005023511,0.0007585243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002746882,"about_ca_system_score_gemma":0.000205021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005333204,"about_ca_topic_score_gemma":0.0006120985,"domain_scores_codex":[0.9998679,0.00001517221,0.00001263982,0.00003795859,0.00003915732,0.00002706385],"domain_scores_gemma":[0.9999107,0.000009272056,0.00003555519,0.000009299605,0.000009226135,0.00002601973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608741,0.00002424804,0.0006253393,0.00003797221,0.000004375652,0.0001018752,0.000014171,0.00008352791,0.9972664,0.0001996269,0.0001210463,0.001360662],"study_design_scores_gemma":[0.00002792437,0.000398854,0.02234213,0.00001158585,0.00001757433,0.0006874945,0.00009459223,0.001119339,0.9703901,0.000145898,0.004757978,0.000006548973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906023,0.0009013662,0.003583724,0.0001621375,0.00005643403,0.00003388175,0.001751332,0.000262589,0.002646259],"genre_scores_gemma":[0.9943001,0.0002888917,0.0009576865,0.00005163611,0.000008582537,0.00003825654,0.0009577879,0.00003858646,0.003358596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003782055,"threshold_uncertainty_score":0.01265228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06613577877352114,"score_gpt":0.4068723488508271,"score_spread":0.340736570077306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}