{"id":"W4402266765","doi":"10.1158/1538-7445.pediatric24-b065","title":"Abstract B065: A phase 1 study of abemaciclib, a CDK 4/6 inhibitor, with radiation in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Cyclin-dependent kinase; Glioma; Oncology; Cancer; Internal medicine; Cancer research; Cell cycle","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130987,0.001368706,0.001851112,0.0004746222,0.0004649251,0.0006557976,0.00107788,0.0009953671,0.002190012],"category_scores_gemma":[0.0005966728,0.0005707159,0.0008555538,0.000516106,0.0009478864,0.0006212954,0.0004207733,0.003146631,0.0006300026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001138298,"about_ca_system_score_gemma":0.002075998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002678693,"about_ca_topic_score_gemma":0.004713971,"domain_scores_codex":[0.9995164,0.0002233906,0.00003164801,0.00008790425,0.00005312857,0.00008754944],"domain_scores_gemma":[0.9993906,0.00009651826,0.00008828442,0.00005457558,0.00004176876,0.0003281747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4830066,0.1658085,0.02454232,0.002154181,0.001629067,0.002469376,0.001060521,0.005598442,0.1401942,0.0006837755,0.004011692,0.1688412],"study_design_scores_gemma":[0.1893594,0.7720958,0.02046257,0.00004536294,0.0003547501,0.001332587,0.00008750041,0.0009147277,0.01215027,0.00009560167,0.003074421,0.00002703191],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939852,0.001478593,0.0004901607,0.0001522272,0.00003982583,0.002126154,0.0005216182,0.00006835078,0.001137874],"genre_scores_gemma":[0.9917907,0.001465235,0.002360895,0.0002826957,0.00007558136,0.00164892,0.001119619,0.00002503591,0.001231515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002678693,"threshold_uncertainty_score":0.008258998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03209554356281608,"score_gpt":0.3941030076058603,"score_spread":0.3620074640430442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}