{"id":"W4402267041","doi":"10.1158/1538-7445.pediatric24-a072","title":"Abstract A072 The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Rhabdomyosarcoma; Medicine; Protein kinase B; PI3K/AKT/mTOR pathway; Cancer research; Oncology; Biology; Signal transduction; Pathology; Sarcoma; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639473,0.0001808732,0.0001894692,0.0002414042,0.0002159974,0.0003665503,0.0001246875,0.0002662508,0.00336406],"category_scores_gemma":[0.0000916511,0.0001383844,0.0002831403,0.0001325475,0.0002013669,0.0001370165,0.0001440952,0.0006223379,0.0008359075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003930231,"about_ca_system_score_gemma":0.0002441644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006950148,"about_ca_topic_score_gemma":0.001028944,"domain_scores_codex":[0.9998889,0.00001545588,0.00001011412,0.00002629766,0.00003574408,0.00002349295],"domain_scores_gemma":[0.9999138,0.00001078748,0.00002628247,0.000009063786,0.00001519845,0.00002482434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001862697,0.00007201559,0.002593771,0.00004821141,0.00001304818,0.0001761538,0.00001859625,0.0001541791,0.9930234,0.0002473477,0.0005170719,0.00294989],"study_design_scores_gemma":[0.0000764293,0.001530214,0.07382307,0.00003177606,0.00005148843,0.002934846,0.0001867937,0.006213333,0.9038408,0.0003904839,0.01090497,0.00001583793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919493,0.00116827,0.002247641,0.0002663144,0.00004388268,0.00005091335,0.0009063367,0.0001981759,0.003169187],"genre_scores_gemma":[0.9954958,0.0003599348,0.001044185,0.00008029374,0.000008464286,0.00002827897,0.0005408234,0.00001954173,0.002422686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00336406,"threshold_uncertainty_score":0.01125389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.106551662736143,"score_gpt":0.4293892089708703,"score_spread":0.3228375462347273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}