{"id":"W4402267417","doi":"10.1158/1538-7445.pediatric24-a075","title":"Abstract A075 GD2-SADA, a bispecific fusion protein that forms self-assembling and disassembling (SADA), GD2-avid tetramers with high affinity for chelated radiolanthanides","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fusion protein; Fusion; Chelation; Bispecific antibody; DOTA; Chemistry; Combinatorial chemistry; Medicine; Biochemistry; Recombinant DNA; Immunology; Organic chemistry; Philosophy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057598,0.0003433098,0.0001313802,0.0001495315,0.0001442875,0.0002220769,0.0002082029,0.0002739245,0.003159523],"category_scores_gemma":[0.00005918004,0.0001157424,0.0002235325,0.0000912201,0.0001976106,0.0001176719,0.0001579201,0.00044369,0.001393813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005334009,"about_ca_system_score_gemma":0.000229211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008298738,"about_ca_topic_score_gemma":0.0006480736,"domain_scores_codex":[0.9999263,0.000007102215,0.000005495971,0.00002208136,0.00002549535,0.00001351138],"domain_scores_gemma":[0.9999518,0.000005820927,0.00001063137,0.000004288564,0.000009337625,0.00001811838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005695946,0.00001484705,0.0001394908,0.00001572828,0.000003867208,0.00002635619,0.000003962256,0.00003374283,0.9986399,0.00009035011,0.0001584495,0.0008164352],"study_design_scores_gemma":[0.00002762719,0.0002494873,0.002447893,0.000004229432,0.00001799997,0.0005294955,0.00001119797,0.001121406,0.9851257,0.00005967503,0.01040183,0.000003569121],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9800217,0.002295048,0.01063387,0.000288657,0.0001307199,0.00008937496,0.001047743,0.0004414126,0.005051473],"genre_scores_gemma":[0.9688442,0.0009286,0.00834408,0.0001953784,0.00003054289,0.00006599668,0.002950454,0.0000781945,0.01856259],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003159523,"threshold_uncertainty_score":0.01056963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1138464093407765,"score_gpt":0.4268385667311418,"score_spread":0.3129921573903654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}