{"id":"W4402267856","doi":"10.1158/1538-7445.pediatric24-b074","title":"Abstract B074: Clonal decomposition and DNA replication states defined by scaled single-cell DNA and RNA sequencing suggest clone-specific therapeutic vulnerabilities in neuroblastoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"clone (Java method); DNA sequencing; Biology; DNA; Computational biology; Cancer research; Molecular biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000250098,0.0001625421,0.0002204323,0.0002552901,0.0001697553,0.0004464707,0.0001488522,0.0003097999,0.00153477],"category_scores_gemma":[0.0003624886,0.0001538067,0.00018061,0.000204078,0.0001885817,0.0002079727,0.0001805787,0.0003379256,0.00044536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003659896,"about_ca_system_score_gemma":0.0001823637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00153602,"about_ca_topic_score_gemma":0.002286981,"domain_scores_codex":[0.9998679,0.000009675992,0.000008102083,0.00005517283,0.000044153,0.00001504263],"domain_scores_gemma":[0.9997824,0.00005445761,0.00005487542,0.00003023093,0.00005560679,0.00002248076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009513108,0.00001045336,0.005542547,0.0000360373,0.00001384259,0.00005668549,0.00004214771,0.0004191456,0.9892579,0.0000839075,0.0001368832,0.004305422],"study_design_scores_gemma":[0.00001280452,0.0003220562,0.2235311,0.00001969592,0.0000869349,0.00120997,0.0001727855,0.008800908,0.759827,0.0005808045,0.00541014,0.00002573396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887077,0.0008002625,0.006776882,0.00006993957,0.00001348287,0.00001947456,0.002119072,0.0002130325,0.001280281],"genre_scores_gemma":[0.9906861,0.0003188317,0.004932975,0.00007372924,0.000005111199,0.00003271182,0.002465836,0.00008892697,0.001395795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153602,"threshold_uncertainty_score":0.005134284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06619053812378871,"score_gpt":0.3749442080172322,"score_spread":0.3087536698934435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}