{"id":"W4402267976","doi":"10.1158/1538-7445.pediatric24-pr010","title":"Abstract PR010: Developing a safe and potent tumor-targeting gated CAR-T cell therapy for DIPG: A deadly pediatric brain tumor","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Brain tumor; CAR T-cell therapy; Tumor cells; Cancer; Cancer research; Oncology; Internal medicine; Immunotherapy; Pathology; Chimeric antigen receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465795,0.0003567708,0.0002183432,0.00016589,0.0001265293,0.000331508,0.0004272234,0.0004031355,0.001376574],"category_scores_gemma":[0.00007968373,0.0001227714,0.0002298817,0.0001501227,0.0002212516,0.0002250021,0.0002453384,0.0007605616,0.0005230714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004860823,"about_ca_system_score_gemma":0.0007003106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401455,"about_ca_topic_score_gemma":0.0009561668,"domain_scores_codex":[0.9998968,0.00001247958,0.00000490508,0.00002360916,0.00003535638,0.00002679175],"domain_scores_gemma":[0.9999685,0.0000037016,0.00000622989,0.000002678837,0.000006543555,0.00001236969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002432013,0.000190102,0.000740802,0.0002504188,0.00001811839,0.0003857284,0.00004052613,0.002305585,0.9637452,0.002957356,0.001541156,0.02758179],"study_design_scores_gemma":[0.000138186,0.001678217,0.001299429,0.00001883078,0.00005429162,0.001446447,0.00002674702,0.01024969,0.9611456,0.0002892739,0.02363994,0.00001328604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8739725,0.005955667,0.1010813,0.001419103,0.0002233642,0.0006016731,0.001119753,0.0009380917,0.01468848],"genre_scores_gemma":[0.9530104,0.002320236,0.03488922,0.0002927413,0.00002135305,0.0002104448,0.00101617,0.00006396085,0.0081755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401455,"threshold_uncertainty_score":0.004605055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07872022883180967,"score_gpt":0.4125548820167345,"score_spread":0.3338346531849248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}