{"id":"W4402270088","doi":"10.7554/elife.101386.1.sa2","title":"eLife Assessment: PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Intron; Craniofacial; Gene expression; Gene; Matrix (chemical analysis); Control (management); Cell biology; Biology; Genetics; Chemistry; Computer science; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005046062,0.0006489654,0.0006798861,0.00022978,0.0001864246,0.0001134122,0.000342092,0.0008626173,0.000388392],"category_scores_gemma":[0.0000768836,0.0006086326,0.0003433703,0.0002514715,0.00003443299,0.000008854932,0.000371312,0.0003974265,0.0001463921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433898,"about_ca_system_score_gemma":0.0006307098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002738828,"about_ca_topic_score_gemma":0.00008877447,"domain_scores_codex":[0.9963265,0.0001386278,0.0009598095,0.001305135,0.000732806,0.0005371128],"domain_scores_gemma":[0.9983221,0.00001010573,0.0003308696,0.0007369167,0.0003771792,0.0002228737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001035609,0.0000314574,0.0000125754,0.001513539,0.0002427007,0.000004537531,0.00001449437,0.0003698896,0.6021799,0.000004573527,0.3913563,0.004166459],"study_design_scores_gemma":[0.0007420103,0.0001143112,0.0006286672,0.002502178,0.0002669551,0.00002593031,0.00000496709,0.00007305456,0.3139338,0.00001090593,0.6810219,0.0006753023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.4298031,0.3194868,0.08269929,0.08459798,0.04485003,0.02512946,0.002838873,0.001585655,0.009008756],"genre_scores_gemma":[0.1112914,0.01499415,0.02462165,0.001883264,0.009238798,0.001732368,0.02495112,0.0005898545,0.8106974],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.8016887,"threshold_uncertainty_score":0.9996365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00976087548006752,"score_gpt":0.2982594097334479,"score_spread":0.2884985342533804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}