{"id":"W4402271104","doi":"10.21203/rs.3.rs-4954000/v1","title":"GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn’s disease","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Indian Institute of Technology Bombay; Crohn's and Colitis Foundation; University of Calgary; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"GPX1; Selenoprotein; GPX4; Programmed cell death; Necroptosis; Immunology; Monocyte; Inflammation; Biology; Pyroptosis; Macrophage; Apoptosis; Cancer research; Glutathione peroxidase; Inflammasome; Oxidative stress; Superoxide dismutase; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096105,0.0004665798,0.0004515234,0.000832774,0.0005327099,0.0005558059,0.0002294772,0.0005991771,0.003778031],"category_scores_gemma":[0.001140646,0.0002441239,0.0002403533,0.0003807984,0.0003372248,0.0002366578,0.0005242529,0.0005604426,0.0004665478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234273,"about_ca_system_score_gemma":0.0001068068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00109721,"about_ca_topic_score_gemma":0.0004848794,"domain_scores_codex":[0.9998098,0.00004294243,0.00002122413,0.00005693886,0.00002942461,0.00003967078],"domain_scores_gemma":[0.9996581,0.00007881285,0.00009776992,0.00003634047,0.00004655678,0.00008243864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009568617,0.0006131331,0.5967944,0.000161093,0.0002500235,0.01049811,0.002253053,0.0001891417,0.366112,0.0003592923,0.001305991,0.01189513],"study_design_scores_gemma":[0.0001629702,0.001035069,0.9705169,0.00004247951,0.0001871653,0.01324019,0.001334055,0.0003733479,0.01103827,0.0005533939,0.001488459,0.00002782009],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995197,0.00007148396,0.00005916854,0.00005632972,0.000009017406,0.000002551652,0.0001097481,0.000003401351,0.0001684713],"genre_scores_gemma":[0.9989876,0.00006613378,0.00007809373,0.00004697304,0.00002026042,0.000005026518,0.0002161625,0.000007957208,0.0005717632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003778031,"threshold_uncertainty_score":0.01263881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05468523769363048,"score_gpt":0.3909138701739049,"score_spread":0.3362286324802744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}