{"id":"W4402271312","doi":"10.1038/s41541-024-00944-7","title":"M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge","year":2024,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Manitoba; Université du Québec à Montréal; Public Health Agency of Canada; Canadian Food Inspection Agency","funders":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; International Development Research Centre; Canadian Food Inspection Agency; Global Affairs Canada; Bill and Melinda Gates Foundation","keywords":"Influenza A virus subtype H5N1; Virology; Hemagglutinin (influenza); Ectodomain; Virus; Biology; Heterologous; Viral matrix protein; Viral shedding; H5N1 genetic structure; Influenza A virus; Highly pathogenic; Antibody; Microbiology; Genetics; Medicine; Disease; Gene; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005766218,0.0005717637,0.0008216909,0.0005172141,0.0002958592,0.0001024302,0.0002599547,0.0001724325,0.0005112679],"category_scores_gemma":[0.0003410242,0.0003648379,0.0002005388,0.0007637708,0.00007972529,0.000215692,0.0002562755,0.0007111795,0.0003048533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001609544,"about_ca_system_score_gemma":0.0002431936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009821818,"about_ca_topic_score_gemma":0.0003146884,"domain_scores_codex":[0.9966754,0.000119037,0.0006101601,0.0008888205,0.0006429233,0.001063693],"domain_scores_gemma":[0.9983679,0.0001833657,0.00009798428,0.0007134177,0.000400212,0.0002371219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01608327,0.004272246,0.08574437,0.01614697,0.009785237,0.01190972,0.01032384,0.00007739784,0.06598127,0.002631069,0.550502,0.2265426],"study_design_scores_gemma":[0.02400644,0.02238659,0.06503588,0.00639041,0.0009411406,0.001509661,0.001901529,0.0033976,0.05183834,0.00115878,0.8187358,0.002697864],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454566,0.012249,0.00006259068,0.02978597,0.0007917345,0.003488691,0.00007727026,0.001213278,0.006874823],"genre_scores_gemma":[0.9908482,0.002009412,0.0008136163,0.0008870861,0.0006834903,0.0006878108,0.0001033415,0.000153618,0.003813413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2682338,"threshold_uncertainty_score":0.9998804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05007042098110945,"score_gpt":0.3465795883094754,"score_spread":0.2965091673283659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}