{"id":"W4402271312","doi":"10.1038/s41541-024-00944-7","title":"M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge","year":2024,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Manitoba; Université du Québec à Montréal; Public Health Agency of Canada; Canadian Food Inspection Agency","funders":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; International Development Research Centre; Canadian Food Inspection Agency; Global Affairs Canada; Bill and Melinda Gates Foundation","keywords":"Influenza A virus subtype H5N1; Virology; Hemagglutinin (influenza); Ectodomain; Virus; Biology; Heterologous; Viral matrix protein; Viral shedding; H5N1 genetic structure; Influenza A virus; Highly pathogenic; Antibody; Microbiology; Genetics; Medicine; Disease; Gene; Infectious disease (medical specialty); Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041447,0.0002595247,0.0002162849,0.0001152771,0.000069702,0.0001260273,0.000148842,0.0003217876,0.0005564748],"category_scores_gemma":[0.0001223944,0.00008476349,0.0001738101,0.00004268576,0.0001210491,0.0002045395,0.000117086,0.0002529754,0.0001008645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001459565,"about_ca_system_score_gemma":0.0001236985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007760104,"about_ca_topic_score_gemma":0.001670847,"domain_scores_codex":[0.9999158,0.00001243529,0.000006785744,0.00002150081,0.00002612142,0.0000172798],"domain_scores_gemma":[0.9999483,0.000009646096,0.00001298456,0.000003693658,0.00001086001,0.00001455054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002126057,0.00007336155,0.0001308951,0.00003972798,0.000006898831,0.000009716468,0.000008527519,0.00007332525,0.9977277,0.00001487644,0.00002648795,0.001675809],"study_design_scores_gemma":[0.00002874726,0.002402429,0.002443972,0.00000860346,0.00002772682,0.00005594618,0.00002337497,0.0007954577,0.9927084,0.00001493289,0.001485498,0.00000502375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977604,0.0007484116,0.000738135,0.00002789765,0.000038159,0.00001951251,0.00005978844,0.00002503471,0.0005826742],"genre_scores_gemma":[0.9959201,0.0004089187,0.001953836,0.00004944644,0.00001294542,0.00003401767,0.0001399735,0.00001107939,0.001469718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007760104,"threshold_uncertainty_score":0.001861572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05007042098110945,"score_gpt":0.3465795883094754,"score_spread":0.2965091673283659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}