{"id":"W4402276143","doi":"10.3390/ijms25179625","title":"Complement-Mediated Two-Step NETosis: Serum-Induced Complement Activation and Calcium Influx Generate NADPH Oxidase-Dependent NETs in Serum-Free Conditions","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Neutrophil extracellular traps; Complement system; Cell biology; NADPH oxidase; Classical complement pathway; Innate immune system; Alternative complement pathway; Complement membrane attack complex; CD59; Chemistry; Biology; Immunology; Reactive oxygen species; Inflammation; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003442381,0.0006679714,0.000342696,0.0002501026,0.0001616161,0.0003331168,0.0002734493,0.000410708,0.0008172807],"category_scores_gemma":[0.0002095402,0.0001307876,0.0004267156,0.000136564,0.0002256066,0.0004096944,0.0003982907,0.0004236452,0.0001693602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000630066,"about_ca_system_score_gemma":0.0003329936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109437,"about_ca_topic_score_gemma":0.001602904,"domain_scores_codex":[0.9996805,0.00005170372,0.00002945472,0.00005578723,0.000104405,0.00007812919],"domain_scores_gemma":[0.9998702,0.00002200897,0.00004318272,0.00001505949,0.0000266461,0.00002293428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002065958,0.00002596845,0.0006104458,0.0001365087,0.00001284064,0.0001626823,0.00002100355,0.00006780981,0.9969357,0.0002459602,0.0000429038,0.001531641],"study_design_scores_gemma":[0.00002330742,0.0002375625,0.008698755,0.00001225835,0.00002021894,0.0004376871,0.00001974795,0.001977411,0.9875749,0.0001333453,0.0008569268,0.000007954247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770333,0.003832667,0.01619205,0.0001737861,0.00008297186,0.0002124653,0.00045764,0.000107144,0.001907923],"genre_scores_gemma":[0.9907986,0.0007813982,0.006350236,0.00008181569,0.00001651542,0.00008981833,0.000366195,0.000005816607,0.001509609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001109437,"threshold_uncertainty_score":0.004571497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03424624953834497,"score_gpt":0.3188937394318357,"score_spread":0.2846474898934908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}