{"id":"W4402285846","doi":"10.21203/rs.3.rs-4913610/v1","title":"Targeting de novo purine biosynthesis for tuberculosis treatment","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Innovation Saskatchewan","keywords":"Tuberculosis; De novo synthesis; Biosynthesis; Purine; Medicine; Biology; Computational biology; Biochemistry; Gene; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001223484,0.000398817,0.0003491821,0.000267344,0.0002096877,0.0002199697,0.0005833735,0.0008204817,0.00007328606],"category_scores_gemma":[0.000929968,0.0003361253,0.0005583153,0.0002289174,0.0002145564,0.00000140896,0.002454008,0.0008070222,0.00007452245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003324638,"about_ca_system_score_gemma":0.0008418714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001937022,"about_ca_topic_score_gemma":0.0000335882,"domain_scores_codex":[0.9962887,0.000299249,0.0003149924,0.001283954,0.000601001,0.001212126],"domain_scores_gemma":[0.9980639,0.0001298339,0.00004056134,0.0008777081,0.000517307,0.0003706834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000299049,0.0003127175,0.0001698877,0.002273918,0.0005173518,0.00005959429,0.00007052427,0.00006630152,0.9709147,0.0001737368,0.01333919,0.01180306],"study_design_scores_gemma":[0.0003959084,0.0007906698,0.00003404244,0.0003451017,0.00005722783,0.00001363039,0.00009445243,0.0005303195,0.8696681,0.00227352,0.1254031,0.0003939394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595575,0.02676876,0.001075101,0.005282264,0.0002616408,0.003389874,0.001379528,0.00009531262,0.002189967],"genre_scores_gemma":[0.9821749,0.005034962,0.002485699,0.000062878,0.001579294,0.002422019,0.001852015,0.0001689493,0.00421923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1120639,"threshold_uncertainty_score":0.9999091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04615237127346076,"score_gpt":0.3982489150501144,"score_spread":0.3520965437766537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}