{"id":"W4402288943","doi":"10.1210/endrev/bnae025","title":"Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease","year":2024,"lang":"en","type":"review","venue":"Endocrine Reviews","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Immunity; Host (biology); Disease; Biology; Immunology; Medicine; Immune system; Ecology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004275019,0.0008035347,0.002240281,0.0002578037,0.0000711702,0.00008886196,0.000351817,0.0001615334,0.0000388735],"category_scores_gemma":[0.00009345536,0.000492047,0.001033886,0.0003024573,0.0000788104,0.000006295597,0.0002706869,0.000641918,0.0001745437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004299177,"about_ca_system_score_gemma":0.0004455174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215541,"about_ca_topic_score_gemma":0.00002455355,"domain_scores_codex":[0.9968853,0.0007937392,0.0008843985,0.0007711822,0.0001140248,0.0005513398],"domain_scores_gemma":[0.998552,0.00002094965,0.0002786653,0.0008559633,0.00002699517,0.0002654286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005428271,0.0001698043,0.000008674345,0.0265284,0.0003265688,0.00006899014,0.00001521664,3.395585e-7,0.0007407019,0.0001589761,0.001176679,0.9707513],"study_design_scores_gemma":[0.000207951,0.0001072269,0.0004860573,0.004770189,0.001771342,0.0001102636,0.000002590279,0.00000141381,0.00001121813,0.00001943862,0.9920664,0.0004458429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005160621,0.9965768,0.000003747119,0.00009737033,0.000301796,0.002216632,0.0002024731,0.00001698584,0.00006807631],"genre_scores_gemma":[0.00115111,0.9968411,0.00003687103,0.0002171797,0.0004630701,0.0001807033,0.0005209515,0.0001002249,0.0004888178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9908898,"threshold_uncertainty_score":0.9997531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281115745302139,"score_gpt":0.3778726847536666,"score_spread":0.3450615273006452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}