{"id":"W4402309270","doi":"10.1039/d4lc00715h","title":"Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide","year":2024,"lang":"en","type":"article","venue":"Lab on a Chip","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Graphene; Interstitial fluid; Nanotechnology; Biocompatibility; microRNA; Hyaluronic acid; Chemistry; Biomedical engineering; Materials science; Biochemistry; Pathology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915395,0.0002679404,0.0002251593,0.0002931773,0.0001135657,0.00003684017,0.0001167058,0.0001982713,0.0001531334],"category_scores_gemma":[0.00001405105,0.0002297558,0.0000491282,0.0004349458,0.0002104851,0.0001713316,0.00003694921,0.0008179426,0.00002392533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338495,"about_ca_system_score_gemma":0.00006351584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000239401,"about_ca_topic_score_gemma":0.0004636203,"domain_scores_codex":[0.9985939,0.0002187934,0.0002767029,0.000429729,0.000114565,0.0003662727],"domain_scores_gemma":[0.9995628,0.0001408466,0.0000444393,0.0001190652,0.00002967582,0.0001031506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003311843,0.0005150884,0.001882377,0.000337496,0.0003751916,0.0004465587,0.003228104,0.001514656,0.8997086,0.0003081016,0.000100323,0.08827163],"study_design_scores_gemma":[0.003150403,0.0005789487,0.0005619681,0.0004931311,0.0001817238,0.0001702572,0.0005411188,0.06167227,0.9151326,0.0004617949,0.01656538,0.0004903549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994699,0.001382034,0.002165443,0.0001219955,0.0005417011,0.0004806013,0.00004967476,0.0001294361,0.0004300979],"genre_scores_gemma":[0.9980764,0.0003481953,0.0005712722,0.0007121802,0.00007903597,0.00005081634,0.00001858432,0.00004237286,0.0001011892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08778127,"threshold_uncertainty_score":0.9369169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04938815442349379,"score_gpt":0.352734752469738,"score_spread":0.3033465980462442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}