{"id":"W4402311649","doi":"10.1016/j.eururo.2024.08.021","title":"Association of Declining Prostate-specific Antigen Levels with Clinical Outcomes in Patients with Metastatic Castration-resistant Prostate Cancer Receiving [177Lu]Lu-PSMA-617 in the Phase 3 VISION Trial","year":2024,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of British Columbia","funders":"National Cancer Institute; Medical Research Council; Novartis Pharmaceuticals Corporation; Novartis","keywords":"Medicine; Prostate cancer; Glutamate carboxypeptidase II; Oncology; Prostate; Prostate-specific antigen; Internal medicine; Antigen; Castration; Clinical trial; Urology; Cancer; Immunology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002136065,0.0005454074,0.00130381,0.0001898598,0.0002062598,0.0008300253,0.0003937024,0.0007058188,0.0006968045],"category_scores_gemma":[0.001490216,0.0002551601,0.001366425,0.0002658757,0.0005376552,0.0003999292,0.0002715836,0.001125451,0.0001199325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005691797,"about_ca_system_score_gemma":0.001056509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008386204,"about_ca_topic_score_gemma":0.00169203,"domain_scores_codex":[0.9992717,0.0004403597,0.00003912308,0.00008765265,0.00007045359,0.00009081246],"domain_scores_gemma":[0.9990085,0.0002856768,0.0003186222,0.00006602726,0.00004545173,0.0002757419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8382224,0.005479275,0.1031413,0.0002932049,0.002134114,0.0001265341,0.0001433978,0.001564783,0.01180602,0.0001141813,0.0007322045,0.03624264],"study_design_scores_gemma":[0.1539318,0.4553345,0.3789621,0.00004598603,0.002243799,0.0003734798,0.000112748,0.003652215,0.003423831,0.0003539386,0.001479351,0.00008610506],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990639,0.0005443419,0.00004254772,0.00003823101,0.00001163003,0.00006442449,0.00006857015,0.00000595585,0.0001604508],"genre_scores_gemma":[0.9991376,0.0001872368,0.00008190637,0.00007891362,0.00002584912,0.00006056342,0.0002495647,0.000002106481,0.0001761173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002136065,"threshold_uncertainty_score":0.01129675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07192577697083756,"score_gpt":0.4037422521249225,"score_spread":0.331816475154085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}