{"id":"W4402311649","doi":"10.1016/j.eururo.2024.08.021","title":"Association of Declining Prostate-specific Antigen Levels with Clinical Outcomes in Patients with Metastatic Castration-resistant Prostate Cancer Receiving [177Lu]Lu-PSMA-617 in the Phase 3 VISION Trial","year":2024,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of British Columbia","funders":"National Cancer Institute; Medical Research Council; Novartis Pharmaceuticals Corporation; Novartis","keywords":"Medicine; Prostate cancer; Glutamate carboxypeptidase II; Oncology; Prostate; Prostate-specific antigen; Internal medicine; Antigen; Castration; Clinical trial; Urology; Cancer; Immunology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00268941,0.0002108055,0.0005227514,0.0002548052,0.00006655885,0.00006155363,0.0001298498,0.00005231448,0.00004487156],"category_scores_gemma":[0.00026417,0.0001135212,0.0000743799,0.0005146029,0.0001401919,0.0001567875,0.00003681593,0.0005439458,0.00001230409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001648508,"about_ca_system_score_gemma":0.0003385156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007315634,"about_ca_topic_score_gemma":0.0003783953,"domain_scores_codex":[0.9964913,0.001250327,0.0008430008,0.0004752703,0.0005329157,0.0004071809],"domain_scores_gemma":[0.9983996,0.0008476109,0.0002737979,0.0002566398,0.0001521454,0.00007020235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07269971,0.001329498,0.9044915,0.00008954402,0.0003562906,0.0007121111,0.004183379,0.00007617179,0.0002746964,0.00001451721,0.000295002,0.01547751],"study_design_scores_gemma":[0.06880692,0.009930166,0.9187332,0.0002259432,0.0001339095,0.000002638458,0.0002745289,0.00009291546,0.000042281,0.00001419429,0.001612882,0.0001303924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945508,0.0005004422,0.00001669846,0.002222005,0.0002424869,0.002008648,0.00009595237,0.00002878837,0.0003341365],"genre_scores_gemma":[0.9987044,0.0002913605,0.000198278,0.0001506439,0.00008362145,0.0000667448,0.0001115002,0.00004738758,0.0003460117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01534712,"threshold_uncertainty_score":0.4629261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07192577697083756,"score_gpt":0.4037422521249225,"score_spread":0.331816475154085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}