{"id":"W4402314510","doi":"10.1016/j.antiviral.2024.105995","title":"Treatment efficacy of cidofovir and brincidofovir against clade II Monkeypox virus isolates","year":2024,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada); Public Health Agency of Canada","funders":"Public Health Agency of Canada","keywords":"Monkeypox; Cidofovir; Outbreak; Virology; Clade; Pandemic; Transmission (telecommunications); Smallpox; Disease; Virus; Biology; Medicine; Infectious disease (medical specialty); Vaccination; Vaccinia; Coronavirus disease 2019 (COVID-19); Gene; Phylogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759578,0.0002743759,0.0003960572,0.0001995673,0.0001358194,0.0002606614,0.0002163859,0.0003153239,0.001331204],"category_scores_gemma":[0.0002774423,0.00009173389,0.0003086307,0.0001027566,0.0001296641,0.0001910872,0.0001011341,0.0004817923,0.00020882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013224,"about_ca_system_score_gemma":0.000175381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056408,"about_ca_topic_score_gemma":0.001042814,"domain_scores_codex":[0.9998609,0.0000323396,0.00001449578,0.00003003042,0.0000229916,0.00003919187],"domain_scores_gemma":[0.9998866,0.00003050261,0.00002099425,0.00001068716,0.00001524301,0.00003593198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00384402,0.001295757,0.001959098,0.0002686194,0.00006647768,0.0001186371,0.0001094066,0.0009555492,0.9653482,0.000111853,0.0005202341,0.02540213],"study_design_scores_gemma":[0.0006111031,0.03665726,0.03469275,0.00005502698,0.0001705389,0.0009335376,0.0001194354,0.002573752,0.9143817,0.00007670599,0.009691059,0.00003714488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935928,0.004156548,0.0003128514,0.00005387242,0.00004757218,0.00004220522,0.0003511717,0.00001988931,0.001422968],"genre_scores_gemma":[0.9965635,0.001370406,0.0005729815,0.00005232921,0.0000238576,0.00003058327,0.000490239,0.000005104703,0.0008910456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331204,"threshold_uncertainty_score":0.004453361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05016156535997781,"score_gpt":0.3652086948991522,"score_spread":0.3150471295391744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}